Susceptibility to Chronic Post-Traumatic Extremity Pain

Status Completed

Clinical Trial Summary

The association between the COMT haplotypes and the presence or absence of CPSP or CRPS will be assessed stratifying the patients based on the individual categories of trauma or elective surgery.

Clinical Trial Description

This will be a prospective association study in which we will recruit patients who have experienced single extremity trauma, or who have scheduled elective surgery on a single extremity. HRQoL will be determined at recruitment. We will identify their haplotypes and genotypes for 4 linked SNPs in the coding region of COMT as described by Diatchenko [2]. Patients will receive follow-up at 3 and 6 months following trauma or surgery. Individuals who report either neuropathic pain or a reduced HRQoL score will be more closely examined, in order to identify CPSP or CRPS. Statistical analyses will be performed to determine whether haplotypes are associated with the development of either condition, and to determine the strength of this association. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00672711
Study type	Observational
Source	William Beaumont Hospitals
Contact
Status	Completed
Phase
Start date	April 2008
Completion date	July 2012

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