The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.

Chronic Cough Clinical Trial

Official title:

The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT01807832
• Other study ID #: TASMC-13-LF-0695-CTIL
• Status: Not yet recruiting
• Phase: N/A
• First received: March 7, 2013
• Last updated: March 7, 2013
• Start date: March 2013
• Est. completion date: December 2013

Study information

• Verified date: March 2013
• Source: Tel-Aviv Sourasky Medical Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: Israel: Ethics Commission
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether the capsaicin challenge can improve the diagnosis, treatment, monitoring and follow-up in patients with chronic cough.

Description:

Capsaicin is administrated in incremental concentrations with two inhalations of normal saline solution. Patients are instructed to exhale to functional residual capacity and than to inhale through the mouthpiece for 1 second (single breath inhalation). The number of coughs in the first 10 seconds after each inhalation is counted. C2; the concentration of which the patient responded by 2 coughs, C5;the concentration of which the patient responded by 5 coughs. The challenge ends at C5.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 25
• Est. completion date: December 2013
• Est. primary completion date: December 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Patients with persisting cough for more than 3 months, without known respiratory or lung diseases

Exclusion Criteria:

• Diagnosis of respiratory or lung diseases of any kind

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• Chronic Cough
• Cough

Intervention

Other:
• capsaicin challenge

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Tel-Aviv Sourasky Medical Center

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	cough reflex hypersensitivity		3 months	No