Sham CPAP vs. Straight CPAP for Chronic Cough

Status Completed

Clinical Trial Summary

Chronic cough is an important clinical problem in primary care and sub-specialty practice. Besides the distress experienced by patients with chronic cough, significant healthcare resources are expended to understand the role of gastroesophageal reflux, asthma and post-nasal drip in understanding their contribution to cough.

Obstructive sleep apnea (OSA) is common in patients with chronic cough. More importantly, treatment of OSA with continuous positive airway pressure (CPAP) has led to improvement in cough for chronic cough patients. Mechanisms by which OSA therapy with CPAP can improve cough includes beneficial effects on reflux and airway inflammation.

The aim of this study is to definitively establish that CPAP therapy for treatment of OSA in chronic cough patients improves cough. While these patients with chronic cough are not routinely screened and treated for OSA, this study aims to evaluate these chronic cough patients with screening questionnaires for OSA and if necessary with polysomnography and randomize them to either CPAP or sham CPAP for 6 weeks.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03172130
Study type	Interventional
Source	University of Utah
Contact
Status	Completed
Phase	N/A
Start date	October 13, 2014
Completion date	November 25, 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05404438` - Mouth Breathing Habits Improvement Intervention	N/A
Recruiting	`NCT05960175` - Impact of Patient Involvement in Alerts Management of Telemonitoring CPAP	N/A
Recruiting	`NCT05813275` - Parallel-Arm Study to Compare AD109 to Placebo With Patients With OSA (SynAIRgy Study)	Phase 3
Completed	`NCT05075668` - Efficacy of HFNC as an Alternative to CPAP Therapy in Surgical Patients With Suspected Moderate to Severe OSA	N/A
Completed	`NCT05881512` - Early Feasibility Study of Transcutaneous Upper Airway Stimulation in Obstructive Sleep Apnea	N/A
Completed	`NCT03336515` - Validity of a Vibrating Postural Device for the Treatment of Positional Obstructive Sleep Apnea (Postural)	N/A
Not yet recruiting	`NCT05944965` - Pharyngeal Muscle Control Mechanisms of Atomoxetine-plus-oxybutynin in Obstructive Sleep Apnea	Phase 1/Phase 2
Completed	`NCT02387476` - Non-Inferiority Study of the FRESCA Mask Versus Existing CPAP Mask for Treatment of Obstructive Sleep Apnea	N/A
Not yet recruiting	`NCT06058052` - Prevalence of OSA in Patients of ILD
Recruiting	`NCT03721445` - Could HRV be a Valuable Predictor for CPAP Adherence?
Recruiting	`NCT06320795` - Prospective Study for the Clinical Validation of the Soundi Wearable Medical Device	N/A
Completed	`NCT01717339` - Sleep Apnea and Vascular Function	N/A
Completed	`NCT00772044` - Randomized Study of Provent Versus Sham Device to Treat Obstructive Sleep Apnea	Phase 4
Completed	`NCT02438137` - Dimethyl Fumarate for Obstructive Sleep Apnea	N/A
Completed	`NCT01672606` - Effect of Rocuronium on the Acute Hypoxic Ventilatory Response in Patients With Obstructive Sleep Apnea	N/A
Completed	`NCT05060133` - Changes of the Upper Airway Volume After Orthognathic Surgery
Completed	`NCT03196583` - Efficacy of a Novel MAD in OSA	N/A
Not yet recruiting	`NCT03933046` - The Association Between Sleep Duration and Sleep Disorders and Proteinuria in Children	N/A
Recruiting	`NCT06091098` - Reversible Effect of Falling Ventilatory Drive in Drive-dependent OSA	N/A
Completed	`NCT02100943` - Exhaled NO as a Biomarker of Gestational OSA and Persistence Postpartum	N/A