Chronic Cough Clinical Trial
Official title:
Neurophysiology and Pharmacology of Cough Reflex Hypersensitivity
A cough lasting more than 2 months is known as a chronic cough, affecting 12-23% of the
adult non-smoking population. Chronic cough has many associated complications including
incontinence, muscular chest pains, blackouts and depression. Current treatment is often
ineffective in these patients. To develop new medications the investigators need to
understand more about the mechanisms that can lead to excessive coughing.
This study plans to compare a group of 12 healthy volunteers and 12 patients with a chronic
cough. The investigators hypothesise that that chronic cough patients have a more sensitive
cough reflex as a result central nervous system hyper-excitability (central sensitisation).
The investigators will measure cough reflex sensitivity before and after administration of
ketamine, a medication that blocks an important receptor in the central nervous system.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Health Services Research
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01432730 -
A Study to Assess the Efficacy of Gefapixant (MK-7264/AF-219), in Participants With Chronic Cough (MK-7264-006)
|
Phase 2 | |
| Not yet recruiting |
NCT01413698 -
Cough Count Validation
|
N/A | |
| Completed |
NCT03639727 -
Cough in Eastern and Central Finland
|
N/A | |
| Completed |
NCT03696108 -
A Study of Gefapixant (MK-7264) in Japanese Adult Participants With Refractory or Unexplained Chronic Cough (MK-7264-038)
|
Phase 3 | |
| Recruiting |
NCT03638063 -
ATP and Capsaicin Cough Provocation Test in Chronic Cough and Bronchiectasis
|
||
| Recruiting |
NCT06376448 -
An Observational Study Using Novel Questionnaire to Characterize Cough Phenotypes in Patients With Chronic Cough
|
||
| Completed |
NCT03172130 -
Sham CPAP vs. Straight CPAP for Chronic Cough
|
N/A | |
| Recruiting |
NCT06286163 -
Neuroinflammatory Interactions of ATP and P2X3 Receptor in the Airways of Chronic Cough Patients
|
||
| Completed |
NCT03622216 -
A Dose Escalation Study of Bradanicline in Refractory Chronic Cough
|
Phase 2 | |
| Recruiting |
NCT05522699 -
Cough Suppressive Therapy in Patients With Chronic Cough
|
N/A | |
| Completed |
NCT01297790 -
Cough Responses to Tussive Agents in Health and Disease
|
N/A | |
| Completed |
NCT04193202 -
Efficacy and Safety of Gefapixant (MK-7264) in Adult Participants With Recent Onset Chronic Cough (MK-7264-043)
|
Phase 3 | |
| Completed |
NCT01865422 -
French Linguistic and Metric Validations of Parent-proxy QOL Chronic Cough Specific Questionnaire (PC-QOL)
|
N/A | |
| Completed |
NCT04525885 -
A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030)-China Extension
|
Phase 3 | |
| Completed |
NCT04193176 -
Efficacy and Safety of Gefapixant (MK-7264) in Women With Chronic Cough and Stress Urinary Incontinence (MK-7264-042)
|
Phase 3 | |
| Recruiting |
NCT05362097 -
Analysis of the Reliability and Validity of the Chinese Version of CC-QoL
|
||
| Recruiting |
NCT03787511 -
Chronic Cough and Small Fiber Neuropathy
|
N/A | |
| Terminated |
NCT03864328 -
A Phase 2b Study of Inhaled RVT-1601 for the Treatment of Persistent Cough in IPF
|
Phase 2 | |
| Completed |
NCT05274516 -
A Trial of HRS-2261 in Healthy Subjects After Single and Multiple Oral Administration
|
Phase 1 | |
| Not yet recruiting |
NCT01807832 -
The Use of Capsaicin Challenge for Diagnosis, Monitoring and Follow-up of Chronic Cough.
|
N/A |