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Cholelithiasis clinical trials

View clinical trials related to Cholelithiasis.

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NCT ID: NCT03482375 Completed - Gall Stones Clinical Trials

Prospective Evaluation of Residual Bile Duct Stone by Peroral Cholangioscopy After Conventional ERCP

Start date: December 17, 2015
Phase:
Study type: Observational [Patient Registry]

Gallstone disease affects over 20 million Americans. Among patients with gallbladder disease, the prevalence of choledocholithiasis (stones in the bile duct) is estimated to be 10-20%. Endoscopic retrograde cholangiopancreatography (ERCP) is considered the standard of care for removing stones in the bile duct utilizing a variety of conventional methods including biliary sphincterotomy, sphincteroplasty, extraction balloon, retrieval basket, and mechanical lithotripsy. After removal of stones from the bile duct, an occlusion cholangiogram is usually performed to confirm complete bile duct clearance. However, cholangiogram can miss residual stones in 11- 30% of cases - especially in the setting of a dilated bile duct, large stones, severe pneumobilia, juxtapapillary diverticulum, primary sclerosing cholangitis, and after lithotripsy (mechanical, electrohydraulic, or laser). The approach to patients with choledocholithiasis requires careful attention because missed bile duct stones can cause recurrent biliary symptoms, pancreatitis, cholangitis, and has significant cost implication with the need for repeat imaging and/or procedures.

NCT ID: NCT03470584 Completed - Stroke Clinical Trials

Vegetarian Diet and Chronic Degenerative Diseases

Start date: March 1, 2005
Phase:
Study type: Observational

To investigate the prospective association between a vegetarian diet and chronic degenerative diseases in two cohorts of Taiwanese Buddhists

NCT ID: NCT03429478 Completed - Clinical trials for Inflammatory Response

Effect of Preoperative Music on Sterile Inflammation Induced by Laparoscopic Surgery

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

Surgery induced sterile inflammation leaves behind a biomolecular footprint measurable by various pro-inflammatory markers e.g. IL-6, CD(Cluster of differentiation)19B, HsCRP(High-sensitivity CRP) etc. Music is a non-pharmacological means in attenuating this inflammatory pathway thereby improving Health related quality of life measurable by improved postoperative convalescence. Correct timing of music application is a lacuna in the knowledge. This research aims at evaluating the effect of preoperative music on sterile inflammation induced by index Laparoscopic Surgery (Laparoscopic Cholecystectomy) and its proposed beneficial effects on patient reported outcomes. A total of 50 patients divided into 2 groups (test and control) will be evaluated in this triple blind randomized controlled study aiming at evaluating the biomolecular signatures of sterile inflammatory response and its correlation with improved postoperative convalescence. All the patients will be followed up for a period of 1 month postoperatively to assess for overall improvement in health related quality of life. Collected data will be analysed using updated SPSS software and a p value of less than 0.05 will be taken as statistically significant in support of the measured indices.

NCT ID: NCT03421340 Completed - Biliary Stones Clinical Trials

Non-Complex Biliary Stones DSC vs ERC

Start date: September 21, 2018
Phase: N/A
Study type: Interventional

To prospectively compare non-complex biliary stone clearance using fluoroscopy/radiation-free direct solitary cholangioscopy (DSC) utilizing the SpyGlass™ system with non-complex biliary stone clearance using standard endoscopic retrograde cholangiography (ERC).

NCT ID: NCT03394807 Completed - Pain Clinical Trials

LaGRA Trial in Laparoscopic Cholecystectomy

LaGRA
Start date: October 1, 2016
Phase: Phase 4
Study type: Interventional

This study investigated the effectiveness of a surgeon administered, laparoscopic guided, regional anaesthesia technique.

NCT ID: NCT03247257 Enrolling by invitation - Cholelithiasis Clinical Trials

Comparing Epidural Versus General Anesthesia for LESS Cholecystectomies

Start date: February 2015
Phase: N/A
Study type: Interventional

This study is a prospective, comparative, controlled, blinded study that will enroll a total of 70 adults that will undergo elective laparoendoscopic single-site incision gallbladder removal. The objective of this study is to compare Epidural versus General Anesthesia for postoperative pain, length of hospital stay, outcomes, and cost of post-cholecystectomy patients.

NCT ID: NCT03247101 Active, not recruiting - Gallstones Clinical Trials

Probiotics for Gallstones in Post-bariatric Surgery Patients:A Prospective Randomized Trial

Start date: February 2016
Phase: N/A
Study type: Interventional

Morbid obesity has become a major global health problem, and the use of bariatric surgery is increasing. One common complication seen following bariatric surgery is the formation of gallstones. Contributing factors to gallstone formation include hypomotility of gall bladder and supersaturation of bile due to rapid weight loss and mobilization of cholesterol. Previous studies revealed oral probiotics could reduce the cholesterol level by as much as 22% to 33%. The possible mechanisms included bile salt hydrolase activity, assimilation of cholesterol by the bacteria, binding of cholesterol to the bacterial cell wall and physiological actions of the end products of short chain fatty acid fermentation. Therefore, the aim of this study was to determine the ability of probiotics to prevent gallstones formation after bariatric surgery and to evaluate the impact of oral administration of probiotics on the post bariatric surgery patients 's quality of life. Gastrointestinal Quality of Life Index is a widely accepted questionnaire for evaluating the quality of life for patients receiving bariatric surgery. It consists of five domains: digestive symptoms; physical function; emotional condition; social condition and effect of medical treatment, which could access the quality of life of bariatric patient effectively and completely.

NCT ID: NCT03244163 Recruiting - Biliary Stones Clinical Trials

Spyglass DS Peroral Cholangioscope Guided LL or EHL Versus BML for Endoscopic Removal of Complicated Bile Duct Stones

Start date: June 14, 2016
Phase: N/A
Study type: Interventional

This study aims to compare the overall rate of endoscopic clearance of complicated bile duct stones by Spyglass DS peroral cholangioscopy guided holmium:YAG laser/electrohydraulic lithotripsy versus conventional BML.

NCT ID: NCT03180229 Completed - Cholelithiasis Clinical Trials

Granisetron Effect on Hemodynamic Changes in Laparoscopic Cholecystectomy

lap
Start date: May 29, 2017
Phase: Phase 4
Study type: Interventional

Propofol is one of the most commonly used anesthetic agents because of its ability to induce rapid and reliable collection. However, hypotension and injection pain in the induction are the most common complications. After induction of propofol; The cardiovascular system depresses, resulting in a drop in blood pressure due to decreased cardiac output and systemic vascular resistance. This may also contribute to the reduction of sympathetic tone activity in the central way, and slight reduction in the number of pulses that develop as a result of increasing vagal activity. İn order to attenuate these hemodynamic undesired effects caused by propofol, various agents were tried such as atropine, ephedrine, volume replacement ringer lactate, ketamine. Ondansetron and granisetron, which are used for postoperative nausea and vomiting prophylaxis, have been used as such. Therefore, ondansetron and granisetron were preventing hypotension induced by post-spinal and general anesthesia induction. The investigator also tried to demonstrate the effect of granisetron, another serotonin type 3 (5-HT3) receptor antagonist for postoperative nausea and vomiting prophylaxis, on induction hypotension and intubation quality after propofol induction in this study

NCT ID: NCT03168555 Completed - Cholelithiasis Clinical Trials

Changes in Bile Acid Homeostasis and Stool Habits After Cholecystectomy

BACH
Start date: June 22, 2017
Phase: Phase 4
Study type: Interventional

Investigate serial plasma samples of fibroblast growth factor 19 (FGF19) after oral stimulation with chenodeoxycholic acid in the same subjects before and after elective cholecystectomy