Gallstones Clinical Trial
Official title:
Probiotics for Gallstones in Post-bariatric Surgery Patients：A Prospective
Morbid obesity has become a major global health problem, and the use of bariatric surgery is
increasing. One common complication seen following bariatric surgery is the formation of
gallstones. Contributing factors to gallstone formation include hypomotility of gall bladder
and supersaturation of bile due to rapid weight loss and mobilization of cholesterol.
Previous studies revealed oral probiotics could reduce the cholesterol level by as much as
22% to 33%. The possible mechanisms included bile salt hydrolase activity, assimilation of
cholesterol by the bacteria, binding of cholesterol to the bacterial cell wall and
physiological actions of the end products of short chain fatty acid fermentation. Therefore,
the aim of this study was to determine the ability of probiotics to prevent gallstones
formation after bariatric surgery and to evaluate the impact of oral administration of
probiotics on the post bariatric surgery patients 's quality of life.
Gastrointestinal Quality of Life Index is a widely accepted questionnaire for evaluating the
quality of life for patients receiving bariatric surgery. It consists of five domains:
digestive symptoms; physical function; emotional condition; social condition and effect of
medical treatment, which could access the quality of life of bariatric patient effectively
and completely.
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