Childhood Obesity Clinical Trial
Official title:
Evidence-Based Approach to Dietary Management of Prader-Willi Syndrome (PWS)
The overall objective is to explore the mechanisms by which macronutrients regulate food
intake and weight gain in Prader Willi Syndrome (PWS).
Previous studies from the investigators' labs suggest that the increased appetite of PWS may
be triggered or maintained by an increase in the levels of ghrelin, an appetite-stimulating
hormone produced primarily by the stomach. This study will compare the effects of low
carbohydrate diet versus low fat diet on levels of ghrelin, appetite suppressing hormones
and markers of insulin sensitivity in patients with PWS.
The investigators hypothesize that the low carbohydrate diet will suppress plasma active
ghrelin and increase appetite-suppressing hormones to a greater degree and for longer
duration than the low fat diet and will thereby reduce hyperphagia and increase satiety. The
investigators also hypothesize that the low carb diet will improve hormonal and metabolic
markers (fatty acids, amino acids and organic acids) of insulin sensitivity and inflammatory
cytokine profiles of children with PWS.
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label
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