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Dopaminergic Enhancement of Learning and Memory in Aphasia

Cerebrovascular Accident Clinical Trial

Official title:
Dopaminergic Enhancement of Learning and Memory (LL_001, Project on Aphasia)

Clinical Trial Summary

The purpose of this study is to determine whether levodopa, in combination with a high frequency language training, is effective in boosting naming performance in patients with aphasia.

Clinical Trial Description

Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether daily administration of levodopa, coupled with several hours of language training every day, will significantly improve naming abilities in patients with aphasia as compared to placebo administration. We furthermore examine with magnetic resonance imaging which brain regions need to be functionally intact for a dopaminergic improvement of language therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00102869
Study type Interventional
Source University Hospital Muenster
Contact
Status Completed
Phase Phase 4
Start date January 2005
Completion date December 2008
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