Cataract Clinical Trial
Official title:
Clinical and Molecular Studies in Families With Congenital or Hereditary Cataracts
The objective of this study is to discover the genes responsible for the development of
hereditary cataracts in families. A cataract is clouding of the lens of the eye that
obstructs the passage of light and may impair vision. Information from this study may
provide a better understanding of why hereditary cataracts form and perhaps lead to the
development of a test that can predict who will likely be affected and to what degree.
Patients or family members of patients with inherited cataracts who participate in this
study will be asked questions about their family history, especially concerning eye disease
or cataracts, and a family tree will be drawn. They will undergo a complete eye examination,
including photographs to document the clarity or opacity of the lens. In addition, a small
blood sample will be drawn for use in gene mapping studies of inherited cataract.
Status | Completed |
Enrollment | 1200 |
Est. completion date | March 2003 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A and older |
Eligibility |
The proband must have documentation of congenital or hereditary cataract. Patients with cataract due to radiation, steroid, or associated with other ocular diseases such as uveitis, retinitis pigmentosa etc. and age-related cataracts will be excluded. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Eye Institute (NEI) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Eye Institute (NEI) |
United States,
Hejtmancik JF. The genetics of cataract: our vision becomes clearer. Am J Hum Genet. 1998 Mar;62(3):520-5. — View Citation
Padma T, Ayyagari R, Murty JS, Basti S, Fletcher T, Rao GN, Kaiser-Kupfer M, Hejtmancik JF. Autosomal dominant zonular cataract with sutural opacities localized to chromosome 17q11-12. Am J Hum Genet. 1995 Oct;57(4):840-5. — View Citation
Scott MH, Hejtmancik JF, Wozencraft LA, Reuter LM, Parks MM, Kaiser-Kupfer MI. Autosomal dominant congenital cataract. Interocular phenotypic variability. Ophthalmology. 1994 May;101(5):866-71. — View Citation
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