Prostate Cancer Clinical Trial
Official title:
A Phase 3, Randomized, Double-blind, Controlled Trial of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer
Bone metastases and associated pain are a major cause of morbidity and mortality in
castration-resistant prostate cancer (CRPC). Most approved therapies have shown some ability
to reduce soft tissue lesions but none meaningfully impacts bone metastases (as demonstrated
by lack of resolution of lesions on bone scan with these agents) or the pain associated with
these metastases.
This study will evaluate the effect of cabozantinib versus mitoxantrone plus prednisone on
pain response and bone scan response in men with CRPC.
n/a
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