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Clinical Trial Summary

Chronic kidney disease (CKD) is associated with an increased cardiovascular mortality. In particular children with early-onset CKD have a lifelong increased risk to suffer from cardiovascular disease (CVD). Therefore, children with CKD deserve our attention. The immune system in children with CKD is disturbed, exhibiting pro-inflammatory features. Therefore, we aim to learn more about the characteristics of the immune system in early-onset CKD. In this project PBMC of pediatric CKD patients and age-matched healthy controls will be analysed and compared using CITE-Seq as a multimodal scRNAseq phenotyping method. All patients will be clinically characterized to integrate cardiovascular and immunological data.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04976010
Study type Observational
Source Charite University, Berlin, Germany
Contact
Status Completed
Phase
Start date July 17, 2021
Completion date November 19, 2021

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