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Single Cell Leukocyte Landscapes and Cardiovascular Risk in Children With Chronic Kidney Disease

Cardiovascular Diseases Clinical Trial

Official title:
Single Cell Leukocyte Landscapes and Cardiovascular Risk in Children With Chronic Kidney Disease

Clinical Trial Summary

Chronic kidney disease (CKD) is associated with an increased cardiovascular mortality. In particular children with early-onset CKD have a lifelong increased risk to suffer from cardiovascular disease (CVD). Therefore, children with CKD deserve our attention. The immune system in children with CKD is disturbed, exhibiting pro-inflammatory features. Therefore, we aim to learn more about the characteristics of the immune system in early-onset CKD. In this project PBMC of pediatric CKD patients and age-matched healthy controls will be analysed and compared using CITE-Seq as a multimodal scRNAseq phenotyping method. All patients will be clinically characterized to integrate cardiovascular and immunological data.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04976010
Study type Observational
Source Charite University, Berlin, Germany
Contact
Status Completed
Phase
Start date July 17, 2021
Completion date November 19, 2021
View Details
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