The Effects of Interrupting Prolonged Sitting With Intermittent Exercise on Postprandial Lipemia

Cardiovascular Diseases Clinical Trial

Official title:

The Effects of Interrupting Prolonged Sitting With Intermittent Exercise on Postprandial Lipemia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03856606
• Other study ID #: 2017-11-0141
• Status: Completed
• Phase: N/A
• Start date: February 20, 2018
• Est. completion date: July 8, 2018

Study information

• Verified date: February 2019
• Source: University of Texas at Austin
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to investigate the effect of interrupting prolong sedentary behavior with interval exercise on postprandial metabolism following a high fat glucose tolerance test.

Description:

All subjects complete two trials in a randomized crossover design, with each trial occurring over 4 days with a minimum of seven days between trials. The first two days of each trial serve as a control period allowing for familiarization and the control of physical activity and calorie consumption prior to the intervention. Following each control period, subjects then perform one of the interventions on Day 3. The interventions consist of either eight-hours of prolonged sitting, or eight hours of sitting interrupted every hour by five sprints lasting 4 seconds each using the interval exercise. On day 4, all subjects will undergo a high fat glucose tolerance test to determine the body's ability to clear triglycerides from the blood as well as insulin/glucose response and substrate oxidation. Blood samples will be assayed for the previously mentioned substances and postprandial gas collection will be analyzed via indirect calorimetry.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 8
• Est. completion date: July 8, 2018
• Est. primary completion date: July 8, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

Exclusion Criteria:

• cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)

• respiratory problems

• musculoskeletal problems that prevent prolonged sitting or exercise

• susceptibility to fainting

• Pregnancy

Related Conditions & MeSH terms

• Arterial Occlusive Diseases
• Arteriosclerosis
• Atherosclerosis
• Cardiovascular Diseases
• Glucose Metabolism Disorders
• Hyperinsulinism
• Insulin Resistance
• Metabolic Disease
• Metabolic Diseases
• Metabolic Syndrome
• Metabolic Syndrome X
• Vascular Diseases

Intervention

Behavioral:
• Prolonged sitting without exercise
Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial. Day 4 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.
• Prolonged sitting with interval exercise
Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo a prolonged sit which with will be broken up every hour on the hour by a small bout of interval exercise. Day 4 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Locations

Country	Name	City	State
United States	University of Texas at Austin Human Performance Laboratory	Austin	Texas

Sponsors (1)

Lead Sponsor	Collaborator
University of Texas at Austin

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Plasma Triglycerides	Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test	6-hours
Secondary	Plasma Insulin	Areas under the curve for insulin concentration will be calculated for hourly samples from a 6-hour lipid tolerance test	6-hours
Secondary	Plasma Glucose	Areas under the curve for glucose concentration will be calculated for hourly samples from a 6-hour lipid tolerance test	6-hours