Cardiovascular Diseases Clinical Trial
— MCR-CardioVOfficial title:
The "Motoric Cognitive Risk" Syndrome in the Canadian Population: Analysis of Baseline Assessment of the Canadian Longitudinal Study on Aging (CLSA)
Verified date | April 2024 |
Source | Jewish General Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Cognition and locomotion are two human abilities controlled by the brain. Their decline is highly prevalent with aging, and is greater than the simple sum of their respective prevalence, suggesting a complex age-related interplay between cognition and locomotion. Recently, a systematic review and meta-analysis has provided evidence that poor gait performance predicts dementia and, in particular, has demonstrated that "motoric cognitive risk" (MCR) syndrome, which has been described in cognitively healthy individuals and combines subjective cognitive complaint with objective slow gait speed, is a pre-dementia syndrome. The uniqueness of "motoric cognitive risk" (MCR)syndrome is that it does not rely on a complex evaluation or laboratory investigations. Thus, it is easy to apply in population-based settings. The overall objective of the proposal is to examine the epidemiology of the newly reported "motoric cognitive risk" (MCR) syndrome, in the Quebec population using the database of the NuAge study.
Status | Active, not recruiting |
Enrollment | 1461 |
Est. completion date | December 21, 2024 |
Est. primary completion date | August 21, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 45 Years to 85 Years |
Eligibility | Inclusion Criteria: - Individuals eligible for this study will be participants of the NuAge study Exclusion Criteria: - Individuals not eligible for the NuAge study - dementia - mobility disability - no information about cognitive complaint - no measure of walking speed |
Country | Name | City | State |
---|---|---|---|
Canada | Jewish General Hospital | Montréal | Quebec |
Lead Sponsor | Collaborator |
---|---|
Jewish General Hospital |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cardio-vascular risk factors and diseases assessed using reported health condition | medical history | 1 day | |
Secondary | Cardio-vascular risk factors and diseases assessed using physical examination: BMI | body mass index | 1 day | |
Secondary | Cardio-vascular risk factors and diseases assessed using physical examination: HW ratio | hip-waist ratio | 1 day | |
Secondary | Cardio-vascular risk factors and diseases assessed using physical examination: blood pressure | (value of systolic, diastolic when participants are seated in an upright position in a chair) | 1 day | |
Secondary | Disability and functional limitations | Disability and functional limitations : ADL (activities of daily life) | 1 day | |
Secondary | Disability and functional limitations | Disability and functional limitations : IADL (instrumental activities of daily life) | 1 day | |
Secondary | Disability and functional limitations | History of falls during the past 12 months | 12 months | |
Secondary | Depression | measured by the 10 items of the Center for Epidemiological Studies Short Depression Scale. Participants with a score of 10 or greater are considered as depressed. Scores with more than 2 missing items will be excluded. | 1 day | |
Secondary | Cognitive performance | Prospective Memory Test (PMT) | 1 day | |
Secondary | Cognitive performance | Stroop Neurological Screening Test | 1 day | |
Secondary | Cognitive performance | Controlled Oral Word Association Test (FAS) | 1 day | |
Secondary | Cognitive performance | Choice Reaction Time Test (CRT) | 1 day | |
Secondary | physical and mental health | Number of drugs daily taken | 1 day | |
Secondary | physical and mental health | Self-perception of health and mental health | 1 day | |
Secondary | Physical performance | Muscle strength estimated using the handgrip strength | 1 day | |
Secondary | Physical performance | five-time sit-to-stand test | 1 day | |
Secondary | Physical performance | Physical Activity Scale for the Elderly, scored between 0 and 400, low scores indicate sarcopenia | 1 day |
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