Gated SPECT Abnormality With J Point Elevation

Cardiovascular Diseases Clinical Trial

Official title:

The Unidentified Association of Gated SPECT Abnormality With J Point Elevation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03472898
• Other study ID #: 0001
• Status: Completed
• First received: March 15, 2018
• Last updated: March 21, 2018
• Start date: December 27, 2017
• Est. completion date: January 17, 2018

Study information

• Verified date: March 2018
• Source: Ankara Education and Research Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The investigators present an interesting co-incidence of Gated wall abnormality in the inferolateral wall in normal sestamibi myocardial perfusion images with J wave in the inferior derivations of the ECG in a patient. The subsequent coronary angiography demonstrated 80% mid right coronary artery (RCA) stenosis, which was intervened with a drug-eluting stent. The investigators conclude that even though the myocardial perfusion is normal, the association of gated wall abnormality with J wave presentation within the same location should be further evaluated.

Description:

The isolated J-point elevation considered as a type of "early repolarization" pattern (ER), is commonly been regarded as a benign finding. However, ER associations with arrhythmic sudden death from CAD or sudden cardiac death due to either idiopathic ventricular fibrillation have been shown. A recent study reported that ER especially in inferior leads, was related to worse cardiac outcomes in patients with CAD and they argue that ER in patients with CAD seems to be associated with the myocardial scar in the absence of pathologic Q waves.

Likewise, it is rare to detect clinically important gated SPECT abnormalities in normal myocardial perfusion studies with normal transient ischemic dilatation (TID) score and without any right ventricular uptake or any pulmonary uptake. Normal myocardial perfusion findings with wall motion abnormalities are frequently encountered in the interventricular septum of the patients who have previous bypass surgery or in patients with left bundle branch block (LBBB). However, the presented patient did not have the history of any intervention or LBBB. Perfusion and function discordance can be encountered in non-ischemic dilated cardiomyopathy patients; nonetheless, EF is markedly reduced in these patients.

The presented case, J point elevation in the ECG associated with relative wall motion abnormality was an important clue to determine CAD in the lack of evident perfusion defects or significant ECG findings.

The presence of wall motion abnormalities during stress study to predict CAD in patients with normal perfusion pattern, owing to balanced ischemia, was not only reported in multi-vessel disease but also in single-vessel disease without having presented the association between either regional wall motion abnormality or a localized particular ECG pattern and culprit lesion territory.

The interesting part of the presented case is, notwithstanding the myocardial perfusion pattern is normal, the abnormal gated finding with ECG changes having the concordant localization can be a significant milestone on the way to the diagnosis. To the best of investigators knowledge, the association between J point elevation and wall motion abnormality have not been described yet. Therefore, the investigators would like to draw attention to the importance of adjoining trivial ECG changes and wall motion abnormality for readers anymore.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1
• Est. completion date: January 17, 2018
• Est. primary completion date: January 17, 2018
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 55 Years to 55 Years

Eligibility

Inclusion Criteria:

• Case Report

Exclusion Criteria:

Related Conditions & MeSH terms

• Cardiovascular Diseases
• Coronary Artery Disease
• Early Repolarization Syndrome
• Electrocardiogram: Electrical Alternans
• Hypokinesia
• Ischemia
• Left Ventricular Hypokinesia
• Myocardial Ischemia

Locations

Country	Name	City	State
Turkey	AnkaraERH	Ankara	Altindag

Sponsors (1)

Lead Sponsor	Collaborator
Ankara Education and Research Hospital

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Case Report Proposal	Cure	December 2017-January 2018