The European Prospective Investigation Into Cancer in Norfolk Prospective Population Study

Cardiovascular Diseases Clinical Trial

— EPIC-Norfolk  

Official title:

The European Prospective Investigation Into Cancer in Norfolk Prospective Population Study

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03424668
• Other study ID #: MR/N003284/1
• Status: Active, not recruiting
• Start date: January 1, 1992
• Est. completion date: December 31, 2040

Study information

• Verified date: April 2019
• Source: University of Cambridge
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease.

Description:

The European Prospective Investigation into Cancer and Nutrition in Norfolk is a population based prospective study of approximately 25,000 men and women resident in Norfolk United Kingdom. They were aged 39-79 years when first recruited from general practice age sex registers at baseline assessment 1993-1997. While part of a ten country half million participant European collaboration originally aimed to investigate diet and other lifestyle determinants of cancer, the objectives of the Norfolk cohort from inception were expanded to encompass the trajectory of health, ill health and mortality in a population over time and to examine the biological and lifestyle determinants of health and chronic disease. Detailed data on sociodemographic, lifestyle, medical and family history were collected and a biological sample bank including urine and blood samples established. Participants have been followed up through repeat examinations, mailed questionnaires as well as through record linkage with routine health records including death certification by cause, cancer registration and hospital admissions by cause till present.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 25639
• Est. completion date: December 31, 2040
• Est. primary completion date: December 31, 2040
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 39 Years to 79 Years

Eligibility

Inclusion Criteria:

• Willing to participate

• On general practice age sex registers in Norfolk, United Kingdom in 1993-1997

Exclusion Criteria:

• Not willing to participate in study

• terminal illness

Related Conditions & MeSH terms

• Cardiovascular Diseases
• Death
• Neoplasms

Intervention

Behavioral:
• diet
lifestyle factors

Locations

Country	Name	City	State
n/a

Sponsors (3)

Lead Sponsor	Collaborator
University of Cambridge	Cancer Research UK, Medical Research Council

References & Publications (2)

Bingham SA, Welch AA, McTaggart A, Mulligan AA, Runswick SA, Luben R, Oakes S, Khaw KT, Wareham N, Day NE. Nutritional methods in the European Prospective Investigation of Cancer in Norfolk. Public Health Nutr. 2001 Jun;4(3):847-58. — View Citation

Day N, Oakes S, Luben R, Khaw KT, Bingham S, Welch A, Wareham N. EPIC-Norfolk: study design and characteristics of the cohort. European Prospective Investigation of Cancer. Br J Cancer. 1999 Jul;80 Suppl 1:95-103. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	fractures	incident fractures	through 25 years
Other	diabetes mellitus	incident diabetes	through 25 years
Primary	neoplasms	cancer incidence	Through 25 years
Secondary	cardiovascular diseases	incidence of cardiovascular diseases	through 25 years
Secondary	death	total mortality by cause	through 25 years