Cardiovascular Diseases Clinical Trial
Official title:
Differences in Platelet Function in Patients on Abacavir Versus Tenofovir Based Antiretroviral Regimens
Verified date | November 2020 |
Source | University of California, Los Angeles |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This is a small observational study aimed at observing differences in platelet function in HIV patients on abacavir versus tenofovir based anti-HIV drugs. There is some correlation between platelet activation and cardiovascular disease- this study will act as a pilot to see if platelet activation among abacavir users may explain the correlation between abacavir and cardiovascular disease in HIV positive patients. This study will enroll 44 participants total; 22 on abacavir-based treatment, 22 on tenofovir-based treatment. There is only one study visit which includes a blood draw, physical assessment, and review of medical history.
Status | Completed |
Enrollment | 24 |
Est. completion date | February 15, 2020 |
Est. primary completion date | February 15, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - HIV positive - Stable antiretroviral regimen for > 3months containing either abacavir or tenofovir - Suppressed HIV viral load Exclusion Criteria: - Current cigarette smoking - Pre-existing platelet disorder - current or recent (last 6 months) antiplatelet therapy - pregnancy |
Country | Name | City | State |
---|---|---|---|
United States | Clinical AIDS Research and Education Center | Los Angeles | California |
Lead Sponsor | Collaborator |
---|---|
University of California, Los Angeles |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Platelet aggregation | Degree of platelet aggregation in response to adenosine diphosphate | At screening visit | |
Secondary | Plasma Markers of coagulation | sGPVI | At screening visit | |
Secondary | Plasma Markers of Coagulation | sPSelectin | At screening visit | |
Secondary | Plasma markers of endothelial function | sICAM | At screening visit |
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