Specific Respiratory Infections as Triggers of Acute Medical Events

Cardiovascular Diseases Clinical Trial

Official title:

Specific Respiratory Infections as Triggers of Acute Medical Events: Time Series Analysis Using LabBase and Hospital Episode Statistics

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02984280
• Other study ID #: 15/0440
• Status: Completed
• Phase: N/A
• First received: December 2, 2016
• Last updated: May 3, 2017
• Start date: September 2016
• Est. completion date: March 2017

Study information

• Verified date: November 2016
• Source: University College, London
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study will investigate whether there is a population-level association between circulating respiratory viruses and NHS hospital admissions for acute vascular events using data from national infection surveillance and Hospital Episode Statistics.

Description:

We will conduct a time series study correlating anonymised population level data on all samples from NHS laboratories testing positive for six common respiratory viruses with admissions to NHS hospitals in England for a range of cardiac and vascular outcomes over the time period 01/01/2004 to 31/12/2014. This will involve generating Poisson regression models controlling for factors such as seasonal and long-term trends, environmental temperature and humidity.

This study is funded by an Academy of Medical Sciences Starter Grant for Clinical Lecturers.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 787000
• Est. completion date: March 2017
• Est. primary completion date: March 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: 45 Years and older

Eligibility

Inclusion Criteria:

• Any individual with a record of an eligible outcome (ICD-10 coded hospitalisation for myocardial infarction or stroke) within the study period aged 45+ years

• Any individual with a record of an eligible exposure (laboratory-confirmed respiratory virus) within the study period at any age

Exclusion Criteria:

• Outcome events occurring in people aged <45 years

Related Conditions & MeSH terms

• Adenovirus
• Cardiovascular Diseases
• Communicable Diseases
• Human Metapneumovirus Pneumonia
• Infection
• Influenza, Human
• Parainfluenza
• Paramyxoviridae Infections
• Pneumonia
• Respiratory Syncytial Virus Infections
• Respiratory Tract Infections
• Rhinovirus
• Virus Diseases

Locations

Country	Name	City	State
United Kingdom	University College London (UCL)	London

Sponsors (2)

Lead Sponsor	Collaborator
University College, London	Public Health England

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Acute myocardial infarction	ICD-10 coded	01/01/2004 to 31/12/2014
Primary	Stroke	ICD-10 coded	01/01/2004 to 31/12/2014