Cardiovascular Diseases Clinical Trial
Official title:
Comparison of Computer-Driven Protocolized Weaning With Physician-Directed Weaning in Surgical Intensive Care Unit (ICU) Patients
The purpose of this study was to determine whether computer-driven protocolized weaning is superior to physician-directed non-protocolized weaning in over-24-hours-ventilated surgical intensive care unit (ICU) patients. The main hypothesis was that weaning duration differs between both methods. Secondary hypotheses were that reintubation rate, duration of mechanical ventilation, intensive care unit (ICU) length of stay and workload for physicians and nurses differ between both methods.
Since long-term mechanical ventilation is affiliated with a bunch of complications, weaning
affected patients from ventilation as soon as possible is a crucial point. In this context
automated computerized systems have become a torchbearer. These systems are expected to
expedite the weaning process, reduce the duration of mechanical ventilation and ICU length
of stay of a given patient in comparison to conventional physician-directed weaning. A
multicenter randomized trial by Lellouche et al supported these theories, using a
computer-driven system to regulate Pressure Support Ventilation (PSV). This system is now
commercially available as SmartCare/PS (Draeger Medical AG & Co. KG, Luebeck, Germany).
The purpose of the study on hand was to find out whether the results reported before could
be repeated in a broad, surgical ICU patient group. Study design was chosen similar. In
addition we investigated the workload for physicians and nurses in both study arms which has
not been conducted before.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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