Coronary-Prone Behavior and Cardiovascular Reactivity

Cardiovascular Diseases Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00005144
• Other study ID #: 1015
• Secondary ID: R01HL036027
• Status: Completed
• Phase: N/A
• First received: May 25, 2000
• Last updated: February 26, 2016
• Start date: August 1978
• Est. completion date: June 1991

Study information

• Verified date: April 2000
• Source: National Heart, Lung, and Blood Institute (NHLBI)
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Observational

Clinical Trial Summary

To further clarify the concept of coronary-prone behavior and to develop methods of assessing coronary-prone behavior. Specifically, to revise the component scoring system for Potential for Hostility in the Structured Interviews measure of Type A behavior.

Description:

BACKGROUND:

In 1978, a select Review Panel of biomedical and behavioral scientists met under the auspices of the NIH to evaluate the data linking the Type A behavior pattern to coronary heart disease. Based on the scientific evidence available to them in December, 1978, the members of the Panel issued a report in which they concluded that the Type A behavior pattern was an independent risk factor for coronary heart disease, of a magnitude similar to that of other established risk factors, such as cigarette smoking and serum cholesterol.

At the time the Panel met, the most impressive evidence linking the Type A behavior pattern to coronary heart disease was the prospective Western Collaborative Group Study (WCGS), which established a significant risk ratio for Structured Interview-assessed Type A behavior pattern for all clinical manifestations of coronary heart disease; and three angiographic studies which reported significant associations between Structured Interview-defined Type A behavior pattern and severity of coronary artery disease. Supporting evidence was provided by prevalence studies employing the Jenkins Activity Survey (JAS) measure of Type A behavior pattern, and by incidence and prevalence data from the Framingham study, using a six-item scale thought to assess aspects of Type A behavior.

Subsequent to the conference, studies had begun to emerge which called into question the robustness of the association between the Type A behavior pattern and various manifestations of coronary heart disease. The most damaging of these was the prospective Type A study included in MRFIT. In this study, 3,110 men were given the Structured Interview and Jenkins Activity Survey, and followed for an average period of seven years, while receiving annual medical examinations. Analysis of the results at the end of the seven years revealed that Type A behavior pattern, however assessed, was completely unrelated to either coronary death or documented myocardial infarction.

A major tool was the component scoring system for the Structured Interview to determine which of the many attributes comprising the multidimensional Type A behavior pattern were actually associated with coronary heart disease. Component scoring had demonstrated that some components had consistent associations with coronary heart disease, even when the global Type A behavior pattern showed no relationship. Component analysis of the Type A behavior pattern in MRFIT revealed that of all the attributes assessed, only Potential for Hostility was significantly related to incidence of coronary heart disease. Several other studies were conducted under this project. Tape-recorded Structured Interviews from the Western Collaborative Group Study were reanalyzed to assess the relationship between components of Type A behavior and incidence of coronary heart disease. Rescoring was completed on Structured Interviews of over 1,000 subjects who had undergone stress testing while blood pressure and heart rate were recorded. An analysis was also conducted on the influence of cigarette smoking and situational stress on cardiovascular response in young male subjects.

DESIGN NARRATIVE:

In Study I, tape-recorded Structured Interviews from MRFIT were re-scored for Potential for Hostility. In Study II, Structured Interviews were obtained from a new sample of participants in the BLSA. In the BLSA the Structured Interview were expanded to include questions that dealt more directly and sampled more fully antagonistic self-descriptions, attitudes, and behaviors. Alternative measures of Agreeableness-Antagonism were already available from the BLSA sample that were used to validate scores from the expanded Structured Interview, and biomedical information on BLSA participants was used to further test the predictive utility of Antagonistic Hostility as a risk factor for coronary heart disease. Previous research had scored Potential for Hostility from the Structured Interview by examining Content, Intensity, and Style as well as a clinical judgement of Total Potential for Hostility. In the present study, Antagonistic Hostility was measured in terms of Antagonistic Style and Self-Descriptions. A total score was defined as the sum of these two components. Antagonistic Style was scored using a 5-point scale when rudeness, condescension, and disagreeableness were expressed toward the interviewer. Matched and unmatched logistic regressions were used to evaluate Antagonistic Hostility as a risk factor for morbidity and mortality outcomes. Multivariate analyses were used to control for other standard risk factors.

The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. completion date: June 1991
• Accepts healthy volunteers: No
• Gender: Male
• Age group: N/A to 100 Years
• Eligibility: No eligibility criteria

Study Design

N/A

Related Conditions & MeSH terms

• Cardiovascular Diseases
• Coronary Artery Disease
• Coronary Disease
• Heart Diseases

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
National Heart, Lung, and Blood Institute (NHLBI)

References & Publications (62)

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Costa PT, et al: Hostility, Agreeableness-Antagonism and Coronary Heart Disease. J Holistic Med, 1987

Costa PT, McCrae RR, Dembroski TM: Agreeableness vs. Antagonism: Explication of a Potential Risk Factor for CHD. In Siegman A, Dembroski T (Eds), In Search of Coronary-Prone Behavior. Hillsdale, NJ: Lawrence Erlbaum, 1989.

Dembroski TM, Costa PT Jr. Coronary prone behavior: components of the type A pattern and hostility. J Pers. 1987 Jun;55(2):211-35. — View Citation

Dembroski TM, Czajkowski S: Historical and Current Developments in Coronary-Prone Behavior. In: Siegman A, Dembroski T (Eds), In Search of Coronary-Prone Behavior. Hillsdale, NJ, Lawrence Erlbaum, 1989.

Dembroski TM, Halhuber M (Eds.) Psychosocial Stress and Coronary Heart Disease. Berlin: Springer-Verlag, 1980

Dembroski TM, MacDougall JM, Cardozo SR, Ireland SK, Krug-Fite J. Selective cardiovascular effects of stress and cigarette smoking in young women. Health Psychol. 1985;4(2):153-67. — View Citation

Dembroski TM, MacDougall JM, Costa PT Jr, Grandits GA. Components of hostility as predictors of sudden death and myocardial infarction in the Multiple Risk Factor Intervention Trial. Psychosom Med. 1989 Sep-Oct;51(5):514-22. — View Citation

Dembroski TM, MacDougall JM, Eliot RS, Buell JC: A Social-Psychophysiological Model of Biobehavioral Factors and Coronary Heart Disease. In: Spielberger CD, Sarason IG, Defares PB, Stress and Anxiety, Vol. 9, New York, Hemisphere, 1983

Dembroski TM, MacDougall JM, Eliot RS, Buell JC: Stress, Emotions, Behavior, and Cardiovascular Disease. In: Temoshok L, Van Dyke C & Zegans LS (Eds.) Emotions in Health and Illness. San Diego, Grune & Stratton, 1983

Dembroski TM, MacDougall JM, Herd JA, Shields JL: Coronary-Prone Behavior: An Appraisal and Evaluation. In: Dembroski TM, Halhuber M (Eds.) Psychosocial Stress and Coronary Heart Disease. Berlin: Springer-Verlag, 1980

Dembroski TM, MacDougall JM, Herd JA, Shields JL: Effects of Level of Challenge on Pressor and Heart Rate Responses in Type A and B Subjects. J Appl Social Psychol, 9:209-228, 1979

Dembroski TM, MacDougall JM, Herd JA, Shields JL: The Type A Coronary-Prone Behavior Pattern: A Review. Technical Report, National Heart, Lung and Blood Institute, National Institutes of Health, 1980

Dembroski TM, MacDougall JM, Lushene R. Interpersonal interaction and cardiovascular response in type A subjects and coronary patients. J Human Stress. 1979 Dec;5(4):28-36. — View Citation

Dembroski TM, MacDougall JM, Musante L. Desirability of control versus locus of control: relationship to paralinguistics in the type A interview. Health Psychol. 1984;3(1):15-26. — View Citation

Dembroski TM, MacDougall JM, Slaats S, Eliot RS, Buell JC. Challenge-induced cardiovascular response as a predictor of minor illnesses. J Human Stress. 1981 Dec;7(4):2-5. — View Citation

Dembroski TM, MacDougall JM, Williams RB, Haney TL, Blumenthal JA. Components of Type A, hostility, and anger-in: relationship to angiographic findings. Psychosom Med. 1985 May-Jun;47(3):219-33. — View Citation

Dembroski TM, MacDougall JM, Williams RB: Reply to Professor Steptoe. Psychosom Med, 5:371-373, 1986

Dembroski TM, MacDougall JM: Beyond Global Type A: Relationship of Paralinguistic Attributes, Hostility, and Anger-In to Coronary Heart Disease. In: Field T, McCabe P, Schneiderian N (Eds), Stress and Coping, Hillsdale, New Jersey, Lawrence Erlbaum. pp 223-242, 1985

Dembroski TM, MacDougall JM: Coronary-Prone Behavior, Social Psycho-Physiology, and Coronary Heart Disease. In: Eiser JR (Ed) Social Psychology and Behavioral Medicine. London: Wiley, 1980

Dembroski TM, MacDougall JM: Coronary-Prone Behavior, Social Psychophysiology, and Coronary Heart Disease. In: Eiser JR (Ed) Social Psychology and Behavioral Medicine. London, Wiley, 1982

Dembroski TM, MacDougall JM: Stress and Cigarette Smoking: Implications for Cardiovascular Risk. In: Schmidt TH, Dembroski TM, Blumchen G (Eds), Biological and Psychological Factors in Cardiovascular Disease. New York, Springer Verlag. pp 246-257, 1986

Dembroski TM, MacDougall JM: Validation of the Vita-Stat Automated Noninvasive Ambulatory Blood Pressure Recording Device. In: J. A. Herd & S. Weiss (Eds.) Cardiovascular Instrumentation: Applicability of New Technology to Biobehavioral Research. Bethesda, MD: NIH Publication No 84-1654, March 1984

Dembroski TM, Schmidt T, Blumchen G: (Eds.) Biobehavioral Bases of Coronary Heart Disease. New York, Karger, 1983

Dembroski TM, Wiliams RB. Assessment of Coronary-Prone Behavior. In: Schneidermann, et al (Eds), Handbook of Research Methods in Cardiovascular Behavioral Medicine. New York: Plenum Press, 1989

Dembroski TM. Exercise hypertension: behavior and the dynamic action of risk factors. Herz. 1987 Apr;12(2):134-40. — View Citation

Dembroski TM: Behavior and Cardiovascular Response Measurement Through Ambulatory Monitoring. Technical Report, Behavioral Medicine Branch, National Heart, Lung, and Blood Institute, July 1982

Dembroski TM: Behavior Patterns, Stress, and Coronary Disease. Biofeedback and Self-Regulation. (Review), 5:125-130, 1980

Dembroski TM: Cardiovascular Reactivity in Type A Coronary-Prone Subjects. In: Oborne DJ, Gruneberg M, Eiser J, (Eds.) Research in Psychology and Medicine, New York: Academic Press, 1979

Dembroski TM: Coronary-Prone Behavior: An Example of a Current Development in Behavioral Medicine. Natl Forum, 60:5-9, 1980

Dembroski TM: Overview of Classic and Stress-Related Risk Factors: Relationship to Substance Effects on Reactivity. Matthews KA et al (Eds), Handbook of Stress, Reactivity, and Cardiovascular Disease. New York, Wiley, pp 275-289, 1986

Dembroski TM: Physiological and Behavioral Concomitants of the Type A Pattern, In: Dembroski TM, Halhuber M (Eds.) Psychosocial Stress and Coronary Heart Disease. Berlin: Springer-Verlag, 1980

Dembroski TM: Stress and Substance Interaction Effects on Risk Factors and Reactivity. Behav Med Update, 6:16-20, 1984

Dembroski TM: Stress-Substance Interaction and Reactivity. In: Weiss S, Matthews K, Detre T, Graeff J (Eds), Stress, Reactivity, and Cardiovascular Disease. Bethesda, Maryland: NIH Publication No 84-2698, 1984

Eliot RS, Buell JC, Dembroski TM. Bio-behavioural perspectives on coronary heart disease, hypertension and sudden cardiac death. Acta Med Scand Suppl. 1982;660:203-13. — View Citation

Eliot RS, Dembroski TM: Getting to the Heart of Coronary-Prone Behavior. Colloquy, July, 5-7, 1982

Herd JA, Falkner B, Anderson DE, Costa PD Jr, Dembroski TM, Hendrix GH, Henry JP, Kaplan JR, Light KC, Schneiderman N, et al. Psychophysiologic factors in hypertension. Circulation. 1987 Jul;76(1 Pt 2):I89-94. Review. — View Citation

Krantz DS, Contrada RJ, LaRiccia PJ, Anderson JR, Durel LA, Dembroski TM, Weiss T. Effects of beta-adrenergic stimulation and blockade on cardiovascular reactivity, affect, and type A behavior. Psychosom Med. 1987 Mar-Apr;49(2):146-58. Erratum in: Psychosom Med 1987 Jul-Aug;49(4):433. — View Citation

Krantz DS, Durel LA, Davia JE, Shaffer RT, Arabian JM, Dembroski TM, MacDougall JM. Propranolol medication among coronary patients: relationship to type A behavior and cardiovascular response. J Human Stress. 1982 Sep;8(3):4-12. — View Citation

Krantz DS, Schaeffer MA, Davia JE, Dembroski TM, MacDougall JM, Shaffer RT. Extent of coronary atherosclerosis, type A behavior, and cardiovascular response to social interaction. Psychophysiology. 1981 Nov;18(6):654-64. — View Citation

MacDougall JM, Dembroski TM, Dimsdale JE, Hackett TP. Components of type A, hostility, and anger-in: further relationships to angiographic findings. Health Psychol. 1985;4(2):137-52. — View Citation

MacDougall JM, Dembroski TM, Krantz DS. Effects of types of challenge on pressor and heart rate responses in type A and B women. Psychophysiology. 1981 Jan;18(1):1-9. — View Citation

MacDougall JM, Dembroski TM, Musante L. The structured interview and questionnaire methods of assessing coronary-prone behavior in male and female college students. J Behav Med. 1979 Mar;2(1):71-83. — View Citation

MacDougall JM, Dembroski TM, Slaats S, Herd JA, Eliot RS. Selective cardiovascular effects of stress and cigarette smoking. J Human Stress. 1983 Sep;9(3):13-21. — View Citation

MacDougall JM, Musante L, Howard JA, Hanes RL, Dembroski TM. Individual differences in cardiovascular reactions to stress and cigarette smoking. Health Psychol. 1986;5(6):531-44. — View Citation

Matthews KA, Krantz DS, Dembroski TM, MacDougall JM. Unique and common variance in structured interview and Jenkins Activity Survey measures of the type A behavior pattern. J Pers Soc Psychol. 1982 Feb;42(2):303-13. — View Citation

Matthews KA, Rosenman RH, Dembroski TM, Harris EL, MacDougall JM. Familial resemblance in components of the type A behavior pattern: a reanalysis of the California type A twin study. Psychosom Med. 1984 Nov-Dec;46(6):512-22. — View Citation

Matthews KA, Weiss S, Detre T, Dembroski TM, Faulkner B, Manuck S, Williams RB (Eds): Handbook of Stress, Reactivity, and Cardiovascular Disease. New York, Wiley, 1986

Musante L, MacDougall JM, Dembroski TM, Costa PT Jr. Potential for hostility and dimensions of anger. Health Psychol. 1989;8(3):343-54. — View Citation

Musante L, MacDougall JM, Dembroski TM, Van Horn AE. Component analysis of the type A coronary-prone behavior pattern in male and female college students. J Pers Soc Psychol. 1983 Nov;45(5):1104-17. — View Citation

Musante L, MacDougall JM, Dembroski TM: Type A Behavior Pattern and Attributions for Success and Failure. Pers Soc Psychol Bulletin, 10:544-553, 1984

Schmidt TH, Dembroski TM, Blumchen G (Eds): Biological and Psychological Factors in Cardiovascular Disease. New York, Springer Verlag, 1986

Schmidt TH, Dembroski TM, MacDougall JM, Ledig P, Eschweiler J, Thrierse H: Various Perspectives on Cardiovascular Reactivity and the Type A Behavior Pattern. In: Orlebeke J, Mulder G, Van Doornen L (Eds), Psychophysiology of Cardiovascular Control: Models, Methods, and Data. London, Plenum. pp 733-743, 1985

Schmidt TH, Undeutsch K, Dembroski TM, Langosch W, Neus H, Rüddel H. Coronary prone behavior and cardiovascular reactions during the German version of the type A interview and during a quiz. Act Nerv Super (Praha). 1982;Suppl 3(Pt 2):241-51. — View Citation

Schmidt TM, Undeutsch K, Dembroski TM, Hahn R, Langosh W, Neus H, Ruddel H: Kardiovaskullaere Risikofaktoren und Typ-A-Verhalten. Verhandlung Der Deutschen Geselschaft Fuer Innere Medizin, 88, 1204-1209, 1982

Shepherd JT, Dembroski TM, Brody MJ, Dimsdale JE, Eliot RS, Light KC, Miller NE, Myers HF, Obrist PA, Schneiderman N, et al. Biobehavioral mechanisms in coronary artery disease. Acute stress. Circulation. 1987 Jul;76(1 Pt 2):I150-7. Review. — View Citation

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Siegman AW, Dembroski TM, Ringel N. Components of hostility and the severity of coronary artery disease. Psychosom Med. 1987 Mar-Apr;49(2):127-35. — View Citation

Stone SV, Dembroski TM, Costa PT Jr, MacDougall JM. Gender differences in cardiovascular reactivity. J Behav Med. 1990 Apr;13(2):137-56. — View Citation

Streufert S, Streufert S, Dembroski TM, MacDougall JM: Complexity, Coronary-Prone Behavior, and Physiological Response. In: Oborne DJ, Gruneberg M, Eiser J, (Eds.) Research in Psychology and Medicine, New York: Academic Press, 1979

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