Inspiratory Muscle Strength Training in Post-Covid Syndrome

Post-COVID-19 Syndrome Clinical Trial

Official title: The Effects of Based-home High-resistance Inspiratory Muscle Training on Neurovascular Control, Blood Pressure, and Exercise Capacity in Patients With Post-COVID-19 Syndrome

Status Recruiting

Clinical Trial Summary

Patients with post-Covid-19 syndrome are at high risk of developing cardiovascular diseases 12 months after acute infection of COVID-19. We recently revealed that these patients have elevated muscular sympathetic nerve activity (MSNA), vascular dysfunction, impaired cardiac diastolic function, and reduced functional capacity. Considering that these outcomes are independent predictors of cardiovascular mortality, it is urgent to restore the cardiovascular health of these patients. High resistance inspiratory muscle strength training (IMST) at 75% of pressure inspiratory (PImax) performed at home (5 min/session, 5-7 times/week per 6 weeks) reduces the MSNA, improves the endothelial function and lowers blood pressure in different populations. Based on these findings, IMST (75% PImax) is an excellent therapeutic option for patients with post-COVID-19 syndrome. Therefore, the aim of the present proposal is to test whether IMST (75% PImax) reduces sympathetic activity, improves vascular function, and restores cardiac function, evoking an increase in functional capacity in patients with post-COVID-19 syndrome. To test these hypotheses we will conduct a randomized, double-blind, sham-controlled clinical trial to test these hypotheses.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Cardiovascular Abnormalities
• COVID-19
• Physical Exercise
• Post-COVID-19 Syndrome
• Syndrome

• NCT number: NCT06091384
• Study type: Interventional
• Source: D'Or Institute for Research and Education
• Contact: Allan R Sales, PhD
• Phone: 55 21 996482036
• Email: allan.sales@idor.org
• Status: Recruiting
• Phase: N/A
• Start date: October 16, 2023
• Completion date: October 31, 2024