Cancer Clinical Trial
Official title:
Multicentre Perspective Non-interventional Study of Survival Benefits of iCAGES-guided Therapy in Contrast to Standard Therapy or IHC-guided Therapy for Advanced Cancers
NCT number | NCT03192501 |
Other study ID # | ZZiCAGES-001 |
Secondary ID | |
Status | Recruiting |
Phase | |
First received | |
Last updated | |
Start date | July 1, 2017 |
Est. completion date | July 1, 2029 |
This study prospectively evaluates whether the use of iCAGES (integrated CAncer GEnome Score) tool in guiding the treatment of advanced cancers is superior to current standard care or IHC-guided therapy in progress free survival (PFS),overall survival (OS),and improvement of life quality.
Status | Recruiting |
Enrollment | 250 |
Est. completion date | July 1, 2029 |
Est. primary completion date | July 1, 2026 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 70 Years |
Eligibility | Inclusion Criteria: - Pathological and clinical diagnosis of recurrence / metastatic lung cancer or other advanced cancers. - There are PACS images available at the Second Affiliated Hospital of Guangzhou Medical University and the collaborated Hospitals. - The patient is informed consent and signed a written consent. Exclusion Criteria: - Age > 70 or <18 years old. - Previous history of malignant tumors. - Pregnant or lactating female patients. - Any serious concomitant disease that is expected to have an adverse effect on prognosis, including the heart disease that treatment is required, unsatisfactory controlled diabetes and psychiatric disorders. |
Country | Name | City | State |
---|---|---|---|
China | The Second Affiliated Hospital of Guangzhou Medical University | Guangzhou | Guangdong |
Lead Sponsor | Collaborator |
---|---|
Second Affiliated Hospital of Guangzhou Medical University | Sun Yat-sen University, The First Affiliated Hospital of Guangzhou Medical University |
China,
Dong C, Guo Y, Yang H, He Z, Liu X, Wang K. iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing driver genes in personal cancer genomes. Genome Med. 2016 Dec 22;8(1):135. doi: 10.1186/s13073-016-0390-0. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | PFS | The PFS will be recorded during the follow up time. | 2 years | |
Primary | OS | The OS will be recorded during the follow up time. | 2 years | |
Secondary | Quality of life. | Physicians Global Assessment to measure quality of life | 2 years | |
Secondary | Pain | Visual Analog Score for pain | one year |
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