Cancer Clinical Trial
Official title:
Gadofosveset Trisodium (Ablavar, Gdfos) in Distinguishing Hemangiomas and Metastases: A Prospective Trial
The purpose of this study is to determine if Gadofosveset Trisodium (Gdfos, Ablavar) is a useful magnetic resonance imaging (MRI) contrast agent in accurately diagnosing liver metastases compared to the standard agent gadobutrol (EcGd, Gadovist).
The proposed study will be a single centre, prospective trial comparing the sensitivity and
specificity of using Gadofosveset Trisodium (Gdfos, Ablavar) as the MRI contrast agent as
compared to gadobutrol (EcGd, Gadovist).
The study population will include cancer patient's referred for an MRI study of the liver to
rule out metastases. Those who meet the inclusion/exclusion criteria will their routine
(clinical) MRI of the liver with EcGd. They will also receive an additional MRI with Gdfos
within 4 weeks of the original study.
The patient data will be anonymized and the imaging will be read by radiologists and
radiology residents and comparison will be made between the diagnostic accuracy of the
EcGd-enhanced study and the Gdfos-enhanced study.
;
Intervention Model: Single Group Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Diagnostic
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