Cancer Clinical Trial
Official title:
Magnetic Resonance-Guided High Intensity Focused Ultrasound for Palliation of Painful Skeletal Metastases - a Multicenter Study
The aim of this study is to evaluate effectiveness of the Philips Sonalleve MR-HIFU device
for the palliation of pain in patients with bone metastases.
Magnetic Resonance Imaging-guided High Intensity Focused Ultrasound (MR-HIFU) uses ultrasound
to palliate pain caused by bone metastases. The main palliative mechanism of the method is
due to local bone denervation, caused by the heat denaturation of the periosteum layer in the
treated area. The importance of this therapy is that it offers a non-invasive, focal therapy,
avoiding side-effects to surrounding normal tissue that occur with radiation therapy or the
need for needle insertion as with radio-frequency(RF)ablation.
The study hypothesis is that MR-HIFU will be effective in treating the pain associated with
bone metastases
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