Coronary Artery Disease Clinical Trial
Official title:
Artifact-Free High-resolution Myocardial Perfusion MRI in Subjects With Abnormal Nuclear Myocardial Perfusion Studies
This is a pilot study in a patient population with suspected coronary artery disease (CAD) as
defined by the presence of a prior abnormal nuclear (PET/SPECT) myocardial perfusion scan. In
this study design, PET/SPECT will serve as the comparative standard for presence of
myocardial ischemia. We intend to determine the accuracy of an improved magnetic resonance
imaging (MRI) technique for detection of myocardial ischemia in subjects with suspected CAD.
This is not a study to specifically evaluate the efficacy or safety of the drugs but rather
the diagnostic performance of the improved cardiac MRI procedure.
A total of two imaging protocols will be used as "protocol options" in this study (only one
of the protocols will be used for each enrolled subject): (1) "Two-day protocol," which
involves MRI of subjects who have had a recent abnormal PET/SPECT study and includes an
optional second-day visit; (2) "One-day protocol," which involves the subjects undergoing
stress myocardial perfusion SPECT and MRI in the same day.
Two blinded readers will interpret MR and SPECT/PET studies by consensus to assess the
presence of perfusion deficits at stress and rest.
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