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NCT ID: NCT04353609 Recruiting - Autoimmune Diseases Clinical Trials

Covid-19 in Patients With Chronic Inflammatory Rheumatism, Auto-immune or Auto-inflammatory Rare and Non-rare Diseases

covid19 fai2r
Start date: April 18, 2020
Phase:
Study type: Observational

Since December 2019, an international outbreak of respiratory illnesses caused by SARS-CoV-2 called covid-19 has become a global challenge. In France, while the first cases were reported in January, more than 20 000 cases were confirmed at end of March. Early estimations from epidemiological data seem to show that 18-20% of patients with confirmed covid-19 are admitted in an intensive care unit (ICU). Patients with chronic inflammatory rheumatism, auto-immune or auto-inflammatory rare and non-rare diseases are susceptible to severe covid-19 (i.e ICU) due to the specific therapeutic management of their illness (corticosteroid, immunosuppressive and immunomodulatory drugs,..). No data are available for this particular population in France. This retrospective multicentre observational study aims to evaluate the frequency of severe forms of covid-19 and risk factors associated with specific outcomes in covid-19 in patients with chronic inflammatory rheumatism, auto-immune or auto-inflammatory rare and non-rare diseases.

NCT ID: NCT04367857 Recruiting - Covid-19 Clinical Trials

ARMOR Study: COVID-19 Seroprevalence Among Healthcare Workers

Start date: April 18, 2020
Phase:
Study type: Observational [Patient Registry]

The novel coronavirus (SARS-CoV-2) has spread all around the world and testing has posed a challenge globally. Health care providers are highly exposed and are an important group to test. On top of these concerns, health care workers are also stressed by the needs on responders in the COVID-19 crisis. The investigators will look at different ways to measure how common COVID-19 is among health care workers, how common is the presence of antibodies by serological tests (also known as serostatus). The investigators will describe health worker mental and emotional well-being and their coping strategies in their institutional settings. Lastly, the investigators will describe how knowing serostatus can affect individuals' mental and emotional well-being and how to cope in the midst of the COVID-19 response. This will help to how to better test and help healthcare workers in the COVID-19 pandemic and prepare for possible future outbreaks.

NCT ID: NCT04368234 Recruiting - COVID-19 Clinical Trials

Duke COVID-19 Shared Data and Specimen Repository

Start date: April 18, 2020
Phase:
Study type: Observational [Patient Registry]

The purpose of this data repository is to provide a secure and centralized storage location and resource for the collection of essential data and medical specimens, across COVID-19 related protocols at Duke.

NCT ID: NCT04092790 Recruiting - Sarcopenia Clinical Trials

Sarcopenia in Older Patients in the Acute Hospital Setting

Start date: April 18, 2021
Phase: N/A
Study type: Interventional

This study will assess whether the use of technology using the Virtual Gate Device (VGD) will prevent or minimize the development of hospital acquired Sarcopenia resulting from Immobilization.

NCT ID: NCT04521881 Recruiting - Clinical trials for Traumatic Brain Injury

Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

CRASH-4
Start date: April 18, 2021
Phase: Phase 3
Study type: Interventional

Tranexamic acid (TXA) reduces head injury deaths. The CRASH-4 trial aims to assess the effects of early intramuscular TXA on intracranial haemorrhage, disability, death, and dementia in older adults with symptomatic mild head injury

NCT ID: NCT04794738 Recruiting - Pain Clinical Trials

A Clinical Study of SHR8554 Injection for the Treatment of Pain After Orthopedic Surgery

Start date: April 18, 2021
Phase: Phase 2/Phase 3
Study type: Interventional

The primary objective is to evaluate the analgesic efficacy of IV SHR8554 compared with placebo and morphine in patients with acute postoperative pain following orthopedic surgery.

NCT ID: NCT04813653 Recruiting - Clinical trials for Multiple Myeloma in Relapse

Cyclosporine in Combination With Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma Refractory to Carfilzomib and High Expression of PPIA Gene in Myeloma Cells

Start date: April 18, 2021
Phase: Phase 1
Study type: Interventional

This phase 1, open-label, single-arm, prospective, single center study will evaluate the safety, tolerability and efficacy of cyclosporine in combination with carfilzomib and dexamethasone in patients with relapsed and refractory multiple myeloma (RRMM).

NCT ID: NCT04211259 Recruiting - Plasma Cell Myeloma Clinical Trials

Loratadine for the Reduction of G-CSF Induced Bone Pain in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization

Start date: April 18, 2022
Phase: Early Phase 1
Study type: Interventional

This early phase I trial studies how well loratadine works in reducing granulocyte-colony stimulating factor (G-CSF) induced bone pain in patients with multiple myeloma who are undergoing stem cell mobilization. Loratadine is an antihistamine that may help to reduce or control bone pain during the process of stem cell collection in patients with multiple myeloma.

NCT ID: NCT04421365 Recruiting - Laryngeal Dystonia Clinical Trials

Brain-Computer Interfaces in Laryngeal Dystonia

Start date: April 18, 2022
Phase: N/A
Study type: Interventional

The researchers will develop and evaluate the use of adaptive closed-loop brain-computer interface therapeutic intervention in laryngeal dystonia.

NCT ID: NCT04726241 Recruiting - Clinical trials for Acute Myeloid Leukemia

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

Start date: April 18, 2022
Phase: Phase 1/Phase 2
Study type: Interventional

This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.