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NCT ID: NCT05789628 Not yet recruiting - Cervical Cancer Clinical Trials

Discovering Factors in Cervical Cancer Patients' Clinical Trial Experiences

Start date: April 2024
Phase:
Study type: Observational

The percentages of participants in clinical studies haven't always been perfectly representative of a particular group. This research examines the variables that affect a patient's choice to enroll in, discontinue participation in, or resume participation in a clinical trial for cervical cancer. It will also try to analyze data from the perspective of different demographic groups to check for recurring trends which might yield insights for the sake of future cervical cancer studies.

NCT ID: NCT05799378 Not yet recruiting - Clinical trials for Systemic Lupus Erythematosus

Effects of Stopping Hydroxychloroquine in Elderly Lupus Disease

SHIELD
Start date: April 2024
Phase: Phase 3
Study type: Interventional

Hydroxychloroquine (HCQ) is a systemic lupus erythematosus (SLE) medication that has been very effective in reducing lupus disease activity and keeping patients stable with reduced symptoms. Despite a track record of safety with regard to infection compared to traditional immunosuppressive agents, the risk of HCQ retinal toxicity escalates with continued use. Evaluation using sensitive standard of care approaches suggests nearly a third of patients accrue retinal damage. Data are needed to accurately weigh the balance between accumulating ocular exposure of HCQ versus the risk of disease flare in a population that may have more inactive disease than younger patients. The purpose of this trial is to address the safety of withdrawal of HCQ in SLE patients =60 years old. The central hypothesis is that HCQ can be safely discontinued in stable/quiescent patients assessed by validated disease activity and flare instruments in the context of serologic, cytokine and transcriptomic profiling. Patients will be randomized to either the placebo or active arm and followed every 2 months for one year to assess disease activity and flares.

NCT ID: NCT05801770 Not yet recruiting - Clinical trials for Head and Neck Cancer

Discovering Factors in Head and Neck Cancer Patients' Clinical Study Experiences

Start date: April 2024
Phase:
Study type: Observational

Enrollment in clinical trials usually favors a particular demographic group. But there is limited research available to explain what study attributes affect the completion of these specific demographic groups. This trial will evaluate the safety and efficacy of head and neck cancer treatments. The focus will be on tracking the rates of completion and withdrawal among these individuals. It will also try to analyze data from the perspective of different demographic groups to check for recurring trends which might yield insights for the sake of future head and neck cancer studies.

NCT ID: NCT05801796 Not yet recruiting - Ovarian Cancer Clinical Trials

Appraising Medical Trial Experiences of Ovarian Cancer Patients

Start date: April 2024
Phase:
Study type: Observational

Historically, participation in clinical trials has been highly skewed towards specific demographic groups. However, research identifying which trial attributes impact participation, in either positive or negative ways, is limited. This study invites participants to record a wide range of data on their clinical trial experience, with the goal being to identify factors which persistently limit patients' ability to participate in, or complete, a trial in which they were initially interested. Data will be analyzed through a range of demographic lenses, in hopes of discovering patterns which might improve the experience of future ovarian cancer patients.

NCT ID: NCT05811858 Not yet recruiting - Osteoarthritis Clinical Trials

Investigating Medical Research Trends in Osteoarthritis Clinical Trials

Start date: April 2024
Phase:
Study type: Observational

Clinical research participation percentages haven't always been fully representative of a given demographic. The goal is to find out which aspects of a clinical trial may make it more difficult for patients to take part or see it through. The data will be evaluated through different demographic lenses and identify trends that could help improve the experience of future osteoarthritis patients during clinical study.

NCT ID: NCT05811871 Not yet recruiting - Tinnitus Clinical Trials

Assessing Factors in Tinnitus Patients' Clinical Study Experiences

Start date: April 2024
Phase:
Study type: Observational

Clinical trials can sometimes favor certain demographic groups. Additionally, there is limited research that delves into the factors that influence participation in clinical trials, both positive and negative. The goal is to identify the obstacles and challenges that prevent participation in tinnitus clinical studies, as well as the reasons for withdrawal or discontinuation. The insights gained from this study will ultimately benefit those with tinnitus who may be invited to participate in clinical research in the years to come.

NCT ID: NCT05815277 Not yet recruiting - Dental Trauma Clinical Trials

Awareness of Parents About Management of Dental Avulsion

Start date: April 2024
Phase:
Study type: Observational

Aim of the study: assessment of level of awareness of parents about emergency management of permanent teeth avulsion in children

NCT ID: NCT05846880 Not yet recruiting - Multiple Myeloma Clinical Trials

VitD3 Supplementation in Patients With Multiple Myeloma

Start date: April 2024
Phase: Early Phase 1
Study type: Interventional

The goal of this clinical trial is to evaluate post-transplant immune reconstitution and lymphocyte recovery as well as the 3-year progression-free survival of patients with multiple myeloma in two treatment arms. One arm will receive lenalidomide and an intensified regimen of maintenance VitD, and the other arm will receive lenalidomide and a therapeutic regimen of VitD. This clinical trial will also evaluate the overall response rate and survival for both treatment arms.

NCT ID: NCT05857696 Not yet recruiting - Clinical trials for Failed Back Surgery Syndrome

Improvement of Gait by Spinal Stimulation in Patients With Postoperative Chronic Lumbosciatalgia: Pilot Study (GaitStim)

GAITSTIM
Start date: April 2024
Phase: N/A
Study type: Interventional

The purpose of this study is to explore the changes in objective walking parameters induced by medullary stimulation in patients with Fail Back Surgery Syndrome, after chronic stimulation, in comparison with preoperative condition.

NCT ID: NCT05861739 Not yet recruiting - Depression Clinical Trials

The Effect of the Self-Care Support Program on Women With Endometriosis

Start date: April 2024
Phase: N/A
Study type: Interventional

This study, was aimed to evaluate the effect of self-care support program (self-care training in endometriosis + motivational interview) applied to women with endometriosis on quality of life, self-care behaviors, depression, anxiety and stress levels.