Breast Neoplasms Clinical Trial
Official title:
Pectoral Nerves Blocks and Their Effect on Chronic Pain After Breast Cancer Surgery
The purpose of this study is to determine whether pectoral nerves blocks(PECS) would reduce chronic pain at 3 months after modified radical mastectomy(MRM)surgery.
One hundred and forty adult female participants scheduled for elective unilateral modified
radical mastectomy under general anesthesia are randomly allocated to receive either general
anesthesia plus Pecs block(Pecs group, n=70) or general anesthesia alone (control group,
n=70).
After arrived in the operating room,the participants in the control group are accepted the
general anesthesia.Whereas,after anesthesia induction,the participants in the Pecs group
receive an ultrasound-guided Pecs block and a 15 minute observation time prior before the
start of the operation.
Pecs block technology: A broadband (5-12 hertz) linear array probe of Sonosite Edge portable
ultrasound system (Sonosite Inc,Bethel,Washington) is used, with an imaging depth of 4 to 6
cm. After cleaning the infraclavicular and axillary regions with chlorhexidine, the probe is
placed below the lateral third of the clavicle, similar to what is done when performing
infraclavicular brachial plexus block. After recognition of the appropriate anatomical
structures, the skin puncture point is infiltrated with 2% lignocaine, then the block is
performed by using a 20-gauge Tuohy needle. The needle is advanced to the tissue plane
between the pectoralis major and pectoralis minor muscle at the vicinity of the pectoral
branch of the acromiothoracic artery, and 10 mL of 0.35% ropivacaine deposited. In a similar
manner, 20 mL is deposited at the level of the third rib below the serratus anterior muscle
with the intent of spreading injectate to the axilla.
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