Breast Carcinoma Clinical Trial
Official title:
Evaluation of the Clinical Benefit of a Spa Care on the Evolution of Late Fibrosis After Postoperative Radiotherapy for Breast Cancer in Remission
This study evaluates the dermatological life quality six months after spa cares in patients with severe late toxicity involving the skin and / or soft tissues after postoperative radiotherapy for breast cancer. Half of the patients will be treated with a combination of pentoxifylline (PTX) and alpha-tocopherol (Vit E) when Half of the patients will receive skin-oriented spa cares in addition.
The combination of PTX and vit E appears as the standard treatment of radiation induced
fibrosis. Synergism between PTX and Vit E is likely, as treatment with each drug alone is
ineffective. This combination was also positively evaluated in the treatment of
osteoradionecrosis, radiation-induced pelvic neuropathies, pneumoniae as well as bowel
pathologies.
Spa cares are part of the standard treatment of burn scars. Two spa treatments per year
enable the mitigation or disappearance (after several treatments) of pruritus, dysesthesia,
local inflammation, hypertrophy and sclerosis. They promote the healing of chronic
superficial erosions. The spa treatment combines baths, sprays and especially filiform
showers with thermal water jets under high pressure for a few minutes.
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