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Clinical Trial Details — Status: Not yet recruiting

Administrative data

NCT number NCT05892380
Other study ID # AMRI01
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date July 1, 2023
Est. completion date August 1, 2025

Study information

Verified date May 2023
Source Fudan University
Contact Yajia Gu, MD
Phone +8621-64175590
Email cjr.guyajia@vip.163.com
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

This study aims to use a combination of abbreviated protocol and artificial intelligence to automatically identify lesions and make diagnosis without decreasing the diagnostic accuracy of breast cancer, thus enhancing the comfort of patient examination, accelerating the flow of examination and reducing the load of clinical work.


Description:

Full sequence of MRI scan is: MR scan protocol: 1. Magnetic fields and coils: Use MR scanners with high fields of 1.5 T and above with dedicated breast coils. 2. Scanning position: prone position with bilateral breasts naturally draped over the center of the breast coil. The position should ensure that all breast tissue is located in the coil, the skin and breast are not folded, the bilateral breast is symmetrical, the nipple is perpendicular to the ground, and the midline of the sternum is located in the middle line of the coil. 3. Scanning sequence and parameters: T1WI non-fat suppressed sequence, T2WI fat suppressed sequence, dynamic five-phase enhanced T1WI fat suppressed sequence, and diffusion weighted imaging (DWI); delayed sagittal T1W1 fat suppressed sequence. Imaging parameters: the thickness of the scanned layer should be ≤3 mm, the resolution within the layer should be <1.5 mm, and the single scan time should be <2 min. Enhancement scan: Gadobutrol used as the contrast agent, and the injection dose was 0.1 ml/kg, which was injected through the elbow vein at a rate of 2-3 mL/s using a pressure syringe, and 10-20 mL of saline was injected into the tube at the same rate after the contrast agent injection. The T1WI sequences before and after enhancement were preferably fat-suppressed and bilateral mammary glands were imaged simultaneously, and subtraction treatment was recommended. The recommended duration of delayed enhancement scan is 7 min, not less than 5 min. Abbreviated sequences : T1WI + dynamic enhanced T1 phase I + maximum density projection images generated by automatic reconstruction in three directions. No extra sequences are required. By adding artificial inteeligence, a diagnostic performance comparable with full sequences is expected.


Recruitment information / eligibility

Status Not yet recruiting
Enrollment 800
Est. completion date August 1, 2025
Est. primary completion date May 1, 2025
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: 1. Patients with breast lesions detected by ultrasound and mammography that cannot be characterized 2. Patients who were consecutively included in our hospital for breast MRI without treatment 3. Underwent preoperative full-protocol breast MRI 4. Pathological results are available, of which benign lesions can be determined by follow-up Exclusion Criteria: 1. Poor MRI image quality 2. Patients who have been received the biopsy

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
China Fudan university Shanghai Cancer Center Shanghai Shanghai

Sponsors (2)

Lead Sponsor Collaborator
Fudan University Bayer

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Comparison between the diagnostic performance of?AP breast MRI + AI? vs. ?Radiologist?, using the pathological results as golden standard, Comparison of AUC, sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) between?AP breast MRI + AI? vs. ?Radiologist?, using the pathological results as golden standard, 2 years
Secondary Comparison of the scan time of abbreviated and full protocol Comparison of the scan time of abbreviated and full protocol 2 years
Secondary Comparison of the interpretation time of abbreviated and full protocol Comparison of the interpretation time of abbreviated and full protocol. Although abbreviated saves scan time, the interpretation time may increase because the usage of AI. 2 years
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