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NCT05699577 Clinical Trial

Prognostic Value of Some Biochemical Markers in Breast Cancer

Breast Cancer Female Clinical Trial

Official title:
Prognostic Value of Some Biochemical Markers in Breast Cancer

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05699577
Other study ID # Soh-Med-23-01-07
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date February 2023
Est. completion date December 2023

Study information
Verified date January 2023
Source Sohag University
Contact amany f abd alrasol, demonstrator
Phone 01065211221
Email amanyfathy@med.sohag.edu.eg
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

breast cancer is the most common type of cancer in women and first cause of cancer death among them. in Egypt it constitutes 33% of female cancer cases and more than22000 new cases diagnosed each year. there are many prognostic factors for breast cancer as Tumer size, axillary lymph node status, hormonal receptor status, and tumer markers as Ca15-3 and interferon gamma.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 90
Est. completion date December 2023
Est. primary completion date December 2023
Accepts healthy volunteers No
Gender Female
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria: - female patients aged more than or equal 18 year diagnosed with breast cancer - metastatic and non-metastatic cancer premenopausal and postmenopausal female positive and negative hormonal receptors and HER2 receptor taking any systemic treatment taking radiotherapy or not Exclusion Criteria: - female patients less than 18 years patients having comorbid disease. patients with double malignancy

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• serum sample for ELIZA
ELIZA for Ca15-3 and interferon gamma

Locations
Country Name City State
Egypt Sohag University Hospital Sohag

Sponsors (1)
Lead Sponsor Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

References & Publications (4)

Jorgovanovic D, Song M, Wang L, Zhang Y. Roles of IFN-gamma in tumor progression and regression: a review. Biomark Res. 2020 Sep 29;8:49. doi: 10.1186/s40364-020-00228-x. eCollection 2020. — View Citation

Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC. Structure of the IFNgamma receptor complex guides design of biased agonists. Nature. 2019 Mar;567(7746):56-60. doi: 10.1038/s41586-019-0988-7. Epub 2019 Feb 27. — View Citation

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660. Epub 2021 Feb 4. — View Citation

Uygur MM, Gumus M. The utility of serum tumor markers CEA and CA 15-3 for breast cancer prognosis and their association with clinicopathological parameters. Cancer Treat Res Commun. 2021;28:100402. doi: 10.1016/j.ctarc.2021.100402. Epub 2021 May 24. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary serum level of Ca15-3 Tumer marker 6 months
Primary serum level of interferon gamma Tumer marker 6 months
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