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Study of Elacestrant in Combination With Onapristone in Patients With Advanced or Metastatic Breast Cancer — ELONA  

Breast Cancer Clinical Trial

Official title:
An Open-Label, Phase 1b-2 Study of Elacestrant, in Combination With Onapristone in Patients With Estrogen Receptor-Positive, Progesterone Receptor-Positive, HER2-negative Advanced or Metastatic Breast Cancer (ELONA)

Clinical Trial Summary

This is a multicenter, Phase 1b-2 study of elacestrant in combination with onapristone in patients with advanced/metastatic ER+/PgR+/HER2- breast cancer.

Clinical Trial Description

This is a multicenter, phase 1b-2 trial. The phase 1b part of the trial is open label and aims to determine the recommended Phase 2 dose (RP2D) of onapristone and elacestrant when administered together. The Phase 2 part of the trial will evaluate the efficacy and safety of this combination in patients with ER+/PgR+/HER2- advanced/metastatic breast cancer after prior therapy with a CDK4/6 inhibitor. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05618613
Study type Interventional
Source Context Therapeutics Inc.
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date December 2, 2022
Completion date April 30, 2026
View Details
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