Losartan in Prevention of Radiation-Induced Heart Failure

Status Recruiting

Clinical Trial Summary

This study is being done to see if losartan affects the chances of developing radiation-induced heart failure in patients who are receiving radiation therapy as part of standard of care treatment for breast cancer. The interventions involved in this study are: - Losartan - Radiation Therapy (standard of care)

Clinical Trial Description

This is a pilot study examining whether losartan prevents radiation therapy-induced myocardial fibrosis (thickening of the heart tissue), which can cause heart failure, in breast cancer patients receiving radiation therapy. Losartan is an U.S. Food and Drug Administration (FDA) approved drug used to treat hypertension (high blood pressure) and heart failure. The U.S. Food and Drug Administration (FDA) has not approved losartan for use in the treatment of breast cancer. The FDA has approved radiation therapy as a treatment option for breast cancer. The research study procedures include: screening for eligibility and study treatment including evaluations and follow up visits. It is expected participants will be on the study for 1 year. It is expected that about 10 people will take part in this research study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05607017
Study type	Interventional
Source	Massachusetts General Hospital
Contact	Rachel Jimenez, MD
Phone	617-726-8651
Email	rbjimenez@partners.org
Status	Recruiting
Phase	Early Phase 1
Start date	January 1, 2024
Completion date	December 1, 2024

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