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Postoperative Radiation of Patients With Breast Cancer in Extreme Hypofractionation.

Breast Cancer Clinical Trial

Official title:
Postoperative External Beam Whole Breast or Chest Wall Irradiation of Patients With Breast Cancer in Extreme Hypofractionation.

Clinical Trial Summary

Evaluation of treatment toxicity of extreme hypofractionation of the whole breast in five fractions of 5.2 Gy in five consecutive workdays.

Clinical Trial Description

The focus of this phase 2-trial is set on feasibility as well as early and late toxicity rates. One possible disadvantage of extreme hypofractionation could be an increased rate of fibrosis within the irradiated region. Therefore, a closer look will be taken with this prospective trial. In addition, we are planning an accompanying translational research program since hypofractionated schedules are suggested to be more immunogenic in breast cancer. Secondary objectives therefore are: cosmetic outcome, local tumor control, quality of life, dynamic immune status, importance of tumor infiltrating immune cells, overall survival, disease-free survival, feasibility of breath-hold radiation technique. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05452083
Study type Observational
Source University of Erlangen-Nürnberg Medical School
Contact
Status Not yet recruiting
Phase
Start date August 1, 2022
Completion date July 30, 2035
View Details
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