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Clinical Trial Summary

This is a prospective, multi-center, randomized study designed to evaluate the clinical efficacy of cryotherapy combined with compression therapy in preventing albumin-paclitaxel induced peripheral neuropathy.


Clinical Trial Description

All HER-2 negative breast cancer patients received neoadjuvant chemotherapy with four cycles of dose-dense epirubicin and cyclophosphamide (ddEC) followed by four cycles of dose-dense albumin-paclitaxel (ddT). The patients were randomly assigned in a 1:1 ratio to receive cryotherapy combined with compression or no intervention. The primary endpoint was incidence of grade 3 and higher peripheral neuropathy as assessed by NCI-CTCAE V5.0. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05341141
Study type Interventional
Source Peking University
Contact Zhaoqing Fan, MD
Phone +86-10-88197838
Email zhqfan@sina.com
Status Recruiting
Phase N/A
Start date June 10, 2022
Completion date November 2026

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