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Clinical Trial Summary

This study aimed to evaluate the pyrrole imatinib in combination with albumin paclitaxel and trastuzumab to neoadjuvant therapy efficacy and safety of Her2-positive early or locally advanced breast cancer

Clinical Trial Description

Subjects who met the criteria for admission were treated with pyrrotinib combined with albumin-bound paclitaxel and trastuzumab (q3w) neoadjuvant therapy for 4 cycles before surgery, and DCR and ORR were assessed before surgery.All subjects who are suitable for surgery undergo surgery and evaluate their pCR rate (pathological complete remission rate).After the operation, the subjects received adjuvant chemotherapy of epirubicin hydrochloride + cyclophosphamide (q3w) for 4 cycles, and at the same time, according to the researcher's recommendation, they chose the follow-up anti-HER2 treatment plan: it is recommended that subjects who have achieved pCR receive preoperative the same anti-Her2 treatment for 1 year; for non-pCR subjects, T-DM1 or trastuzumab and Pertuzumab can be used for anti-her2 treatment for 1 year.For subjects whose estrogen receptor (ER) and/or progesterone receptor (PR) are positive, endocrine therapy can be started at the end of adjuvant chemotherapy.If there are clinical indications at the end of adjuvant chemotherapy, radiotherapy can be given. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT04917900
Study type Interventional
Source West China Hospital
Contact Ting Luo, post-doctor
Phone 18602866299
Email [email protected]
Status Recruiting
Phase Phase 2
Start date April 1, 2021
Completion date June 30, 2023

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