Breast Cancer Clinical Trial
Official title:
Evaluation of the Effect of Mediterranean Diet on Body Composition, Oxidant Stress and Proinflammatory Markers in Breast Cancer Patients
Verified date | March 2021 |
Source | Aydin Adnan Menderes University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In this study, it was aimed to evaluate the effect of the Mediterranean diet on body composition, oxidant stress and proinflammatory markers in overweight and obese breast cancer women.
Status | Completed |
Enrollment | 25 |
Est. completion date | January 20, 2021 |
Est. primary completion date | December 17, 2019 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 65 Years |
Eligibility | Inclusion Criteria: - At least 18 years old, - BMI value to be =25 kg/m2, - To be diagnosed with breast cancer stage I, II or III, - Being a positive hormone receptor status, one of the biological subtypes of breast cancer, - Having completed chemotherapy and / or radiotherapy treatment at least 6 months before starting the study, - Not applying any treatment for body weight loss, - Accepting to participate in the study, - Perceiving disorder and not having communication problems. Exclusion Criteria: - Being under the age of 18 and over the age of 65, - BMI value to be 40 kg/m2, - Having advanced stage breast cancer (IV and V), - Being diagnosed with cancer or metastasis in other organs, - Being one of the biological subtypes of breast cancer, hormone receptor status being negative, - Using antioxidant vitamin-mineral supplements, - Using herbal supplements, - Being pregnant or planning a pregnancy, - To stop working after starting diet therapy. |
Country | Name | City | State |
---|---|---|---|
Turkey | Aydin Adnan Menderes University, Faculty of Health Sciences, Department of Nutrition and Dietetics | Aydin | Efeler |
Lead Sponsor | Collaborator |
---|---|
Aydin Adnan Menderes University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in body weight | Body weight (kg) was measured using the InBody 270 brand device. | Baseline, 8 weeks | |
Primary | Change in body mass indexs | The BMI is defined as the body mass divided by the square of the body height, and is expressed in units of kg/m^2, resulting from mass in kilograms and height in metres. | Baseline, 8 weeks | |
Primary | Change in fat mass measured by bioelectrical impedance analyzer | Fat mass (kg) was measured using the InBody 270 brand device. | Baseline, 8 weeks | |
Primary | Change in fat-free mass measured by bioelectrical impedance analyzer | Fat-free mass (kg) was measured using the InBody 270 brand device. | Baseline, 8 weeks | |
Primary | Change in resting metabolic rate (RMR) measured by bioelectrical impedance analyzer | RMR (kcal) was measured using the InBody 270 brand device. | Baseline, 8 weeks | |
Primary | Change in interleukin 6 (IL-6) | Blood was drawn from participants for assessment of IL-6 (pg/mL) at the beginning and end of the study after fasting for at least 8 hours | Baseline, 8 weeks | |
Primary | Change in tumor necrosis factor alpha (TNF-a) | Blood was drawn from participants for assessment of TNF-a (pg/mL) at the beginning and end of the study after fasting for at least 8 hours | Baseline, 8 weeks | |
Primary | Change in malondialdehyde (MDA) | Blood was drawn from participants for assessment of MDA (mmol/L) at the beginning and end of the study after fasting for at least 8 hours | Baseline, 8 weeks | |
Primary | Change in total antioxidant status (TAS) | Blood was drawn from participants for assessment of TAS (mmol/L) at the beginning and end of the study after fasting for at least 8 hours | Baseline, 8 weeks | |
Primary | Change in total oxidant status (TOS) | Blood was drawn from participants for assessment of TOS (µmol/L) at the beginning and end of the study after fasting for at least 8 hours | Baseline, 8 weeks | |
Secondary | Change in waist circumference | Waist circumference (cm) was measured with a non-stretch tape measure. | Baseline, 8 weeks | |
Secondary | Change in hip circumference | Hip circumference (cm) was measured with a non-stretch tape measure. | Baseline, 8 weeks | |
Secondary | Change in dietary inflammatory index (DII) | Dietary inflammatory index (DII) was calculated with 3-day food consumption record. | Baseline, 8 weeks | |
Secondary | Change in oxidative stress index (OSI) | The oxidative stress index (OSI) value expressed as a percentage of the ratio of serum total oxidant status (TOS) levels to total antioxidant status (TAS) levels was calculated. | Baseline, 8 weeks |
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