Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT04708093 |
Other study ID # |
Woman health |
Secondary ID |
|
Status |
Completed |
Phase |
N/A
|
First received |
|
Last updated |
|
Start date |
August 1, 2019 |
Est. completion date |
September 1, 2020 |
Study information
Verified date |
January 2021 |
Source |
Cairo University |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Interventional
|
Clinical Trial Summary
study aim is to determine the effect of whole body vibration training (WBVT) on body mass
index, serum prolactin concentration as a risk factors for breast cancer and severity of hot
flashes in obese postmenopausal women.
Description:
Menopause is a physiological process characterized by spontaneous cessation of menstrual
cycle lasting at least 12 months, it is normally occurring in women aged 45 - 55 years .
Postmenopausal women have higher prevalence of menopausal symptoms that significantly affect
their quality of life more than pre- and perimenopausal women .
Increased adiposity, as measured by high body mass index, is associated with more severe
menopausal symptoms also, obese female has a high risk lifestyle for the development of
post-menopausal breast cancer .
The link between BMI and breast cancer risk is likely to be due to increased concentrations
of bioavailable estradiol, which results in turn from an increase in the production of
estrogens by aromatase in the adipose tissue, conversion of hormones in fatty tissue and a
decrease in the serum concentration. This is likely to explain the higher risk of breast
cancer in overweight post-menopausal women .
Menopause is also associated with atherogenic changes, including a worsening of CVD risk
factors and decreased aerobic fitness compared with premenopausal women.
This initially may be due to a decrease in endogenous estrogen levels, and likely further
exacerbated by increased adiposity and reductions in exercise habits or physical activity
levels.
Post menopausal women recorded a high serum prolactin concentration however, they have a
significant chance of normalizing their prolactin levels.
Serum prolactin levels rise transiently after several physiological states including
pregnancy, breast-feeding, exercise, meals, sexual intercourse, minor surgical procedures,
general anesthesia, other forms of acute stress and menopause.
Estrogen is another key regulator of prolactin and has been shown to increase the production
and secretion of prolactin from the pituitary gland. In addition to dopamine and estrogen, a
whole range of other hormones can both increase and decrease the amount of prolactin released
in the body, with some examples being thyrotropin-releasing hormone, oxytocin and
anti-diuretic hormone .
Whole-body vibration training is a promising adjunct intervention therapy for management of
obesity, as there is few evidence that it can reduces body mass index and enhances muscles
strength.
In initial stage of obesity management, WBVT is highly recommended because it allows a mild
joints stress, deconditioning for obese patient with poor motivation because it achieve its
target without provoking an excessive fatigue. In addition, Passive vibrations do not involve
voluntary movement and need a lower contribution of central command, so WBVT is as effective
as aerobic and resistance exercise in reducing fat mass and moderating the deficit of the
relative muscle strength . Lastly, WBVT may be effective in vascular health promotion and
prevention in young obese women.
Whole body vibration training(WBVT) has been recognized as an effective alternative exercise
modality to resistance exercise for its ability in enhancing force and power, generating
capacity in skeletal muscle, increasing bone mass, improving cardiovascular function,
reducing fat mass and moderating the deficit of the relative muscle strength. Unfortunately,
the effect of resistance exercise on prolactin has not been extensively studied .
So, this study was conducted to evaluate the effect of whole body vibration training on BMI,
waist circumference, serum prolactin concentration and hot flashes in obese postmenopausal
women.