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ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer — ABBY  

Breast Cancer Clinical Trial

Official title:
A Phase II Pilot Trial of ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer Patients ("ABBY")

Clinical Trial Summary

This is a Phase II randomized, controlled, open label breast cancer clinical trial. 66 patients will be enrolled. The drugs being studied are hydroxychloroquine (Plaquenil) and abemaciclib (also Verzenio). This research study is testing whether using these drugs to target the disseminated tumor cells in bone marrow can reduce their number or eliminate them. Both hydroxychloroquine and abemaciclib are pills that will be taken twice daily. Both are approved by the FDA

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04523857
Study type Interventional
Source Abramson Cancer Center at Penn Medicine
Contact Lauren Bayne, PhD
Phone 215-615-2367
Email breastcancerclinicaltrials@pennmedicine.upenn.edu
Status Recruiting
Phase Phase 2
Start date November 1, 2021
Completion date December 2028
View Details
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