Breast Cancer Clinical Trial
Official title:
Detection of XIST Gene Deletion by Fluorescence in Situ Hybridization in Patients With Breast Cancer and Its Relation With Different Response to Therapies
NCT number | NCT04093609 |
Other study ID # | Xist |
Secondary ID | |
Status | Not yet recruiting |
Phase | |
First received | |
Last updated | |
Start date | March 1, 2020 |
Est. completion date | March 1, 2022 |
Very little is known about the role of X-inactive specific transcript RNA in human breast
cancer and in regulating different response to therapy .
the relation between the breast cancer predisposing gene BRCA1 & X-inactive specific
transcript RNA has been investigated but still controversial.
Loss of X chromosome inactivation (XCI) is observed in breast cancer . Other studies sheds
light on a possible mechanism of breast carcinogenesis mediated by XIST misbehaviour.
Status | Not yet recruiting |
Enrollment | 1 |
Est. completion date | March 1, 2022 |
Est. primary completion date | March 1, 2021 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years and older |
Eligibility |
Inclusion Criteria: - Newly diagnosed patients of breast cancer admitted to south egypt cancer institute at different stages of the disease Exclusion Criteria: - Other malignant diseases. Male breast cancer . Female with other sex linked diseases . Patients received chemotherapy for breast cancer . |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Assiut University |
Akram M, Iqbal M, Daniyal M, Khan AU. Awareness and current knowledge of breast cancer. Biol Res. 2017 Oct 2;50(1):33. doi: 10.1186/s40659-017-0140-9. Review. — View Citation
Banin Hirata BK, Oda JM, Losi Guembarovski R, Ariza CB, de Oliveira CE, Watanabe MA. Molecular markers for breast cancer: prediction on tumor behavior. Dis Markers. 2014;2014:513158. doi: 10.1155/2014/513158. Epub 2014 Jan 28. Review. — View Citation
Giudice A, Barbieri A, Bimonte S, Cascella M, Cuomo A, Crispo A, D'Arena G, Galdiero M, Della Pepa ME, Botti G, Caraglia M, Capunzo M, Arra C, Montella M. Dissecting the prevention of estrogen-dependent breast carcinogenesis through Nrf2-dependent and independent mechanisms. Onco Targets Ther. 2019 Jun 24;12:4937-4953. doi: 10.2147/OTT.S183192. eCollection 2019. Review. — View Citation
Lima ZS, Ghadamzadeh M, Arashloo FT, Amjad G, Ebadi MR, Younesi L. Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms. J Hematol Oncol. 2019 Apr 11;12(1):38. doi: 10.1186/s13045-019-0725-6. Review. — View Citation
Yue M, Charles Richard JL, Yamada N, Ogawa A, Ogawa Y. Quick fluorescent in situ hybridization protocol for Xist RNA combined with immunofluorescence of histone modification in X-chromosome inactivation. J Vis Exp. 2014 Nov 26;(93):e52053. doi: 10.3791/52053. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | detection of X inactive specific transcript RNA deletion in patients with breast cancer | detection of X inactive specific transcript RNA deletion by fluorescence in situ hybridization in patients with breast cancer and its relation with different response to therapies | 3 years |
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