Breast Cancer Clinical Trial
Official title:
Evaluation of Endometrial Changes in Breast Cancer Women With or Without Hormonal Therapies
A history of breast cancer is a risk factor for the development of endometrial pathologies,
such as typical and atypical glandular hyperplasia, endometrial polyps, uterine fibroids,
endometrial adenocarcinoma and uterine sarcoma, probably due to some common risk factors (eg.
obesity, nulliparity). Even if ethiopathogenesis for breast cancer and endometrial
pathologies is not well established, both genetic factors and hyperestrogenic state may be
play a pivotal role for their development. Indeed, relative hyperestrogenism is also the main
target for the treatment of breast cancer. Currently used therapies for this purpose are
selective estrogen receptor (ER) modulators (SERMs), such as Tamoxifen (TAM), and third
generation non-steroidal aromatase inhibitors (AIs), such as letrozole and anastrozole.
TAM has both agonist and antagonist properties, depending upon the individual target organ
and circulating levels of serum estrogens: on the one hand, it blocks estrogen stimulation in
breast tissue; on the other hand, TAM shows an ER agonist activity in the endometrium that is
able to stimulate proliferation and, in some cases, it causes an increased risk of uterine
pathologies. Women with hormone-dependent breast cancer have to use TAM for five to ten
years. Many reports suggest that the risk of uterine pathologies increases with the time of
administration.
Considering these elements, the primary aim of this study will be to investigate the
incidence of endometrial pathologies, especially of endometrial cancer, in different groups
of breast cancer women undergoing diagnostic hysteroscopy.
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