Breast Cancer Clinical Trial
Official title:
Role of Sorcin and Annexin A3 in Breast Cancer Patients
Breast cancer (BC) is the most common female malignancy worldwide and the second leading
cause of cancer death in women. One in eight women in the United States will develop the
illness in their lifetimes. In Egypt, 37.7% of total cancer cases among women is breast
cancer. A locally advanced disease is very common and total mastectomy is the most commonly
performed surgery. Screening methods and adjuvant therapy following surgery led to a
remarkable decrease in mortality.
Reliable prognostic and predictive markers are needed to guide the selection of the most
appropriate adjuvant therapies for individual patients with breast cancer. In fact, a shift
from defining the cancer patients who should receive chemotherapy on the basis of their
prognostic characteristics to defining the patients who are likely to benefit most from this
modality of adjuvant treatment is currently taking place. Understanding the molecular
mechanisms underlying the spread of cancer cells to distant organs, therefore, is a
prerequisite for the development of novel cancer therapies.
Status | Not yet recruiting |
Enrollment | 80 |
Est. completion date | September 30, 2019 |
Est. primary completion date | August 1, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 20 Years to 75 Years |
Eligibility |
Inclusion Criteria: - breast cancer patients before surgery who are admitted to the South Egypt Cancer Institute, Surgery Department, Assiut University Exclusion Criteria: - • Patients with malignancies elsewhere in the body. - Patients with chronic cardiac diseases. - Getting neoadjuvant chemotherapy. - Renal disease. - Neurodegenerative disease. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
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Assiut University |
Colotti G, Poser E, Fiorillo A, Genovese I, Chiarini V, Ilari A. Sorcin, a calcium binding protein involved in the multidrug resistance mechanisms in cancer cells. Molecules. 2014 Sep 5;19(9):13976-89. doi: 10.3390/molecules190913976. Review. — View Citation
Cubasch H, Joffe M, Ruff P, Dietz D, Rosenbaum E, Murugan N, Chih MT, Ayeni O, Dickens C, Crew K, Jacobson JS, Neugut A. Breast conservation surgery versus total mastectomy among women with localized breast cancer in Soweto, South Africa. PLoS One. 2017 Aug 10;12(8):e0182125. doi: 10.1371/journal.pone.0182125. eCollection 2017. — View Citation
Kim JY, Jung EJ, Park HJ, Lee JH, Song EJ, Kwag SJ, Park JH, Park T, Jeong SH, Jeong CY, Ju YT, Lee YJ, Hong SC. Tumor-Suppressing Effect of Silencing of Annexin A3 Expression in Breast Cancer. Clin Breast Cancer. 2018 Aug;18(4):e713-e719. doi: 10.1016/j.clbc.2017.11.009. Epub 2017 Nov 21. — View Citation
Zeeneldin AA, Ramadan M, Elmashad N, Fakhr I, Diaa A, Mosaad E. Breast cancer laterality among Egyptian patients and its association with treatments and survival. J Egypt Natl Canc Inst. 2013 Dec;25(4):199-207. doi: 10.1016/j.jnci.2013.09.003. Epub 2013 Oct 25. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Role of SORCIN in patients with breast cancer | genetic expression of SORCIN new biomarker in breast cancer patients | 1 year | |
Secondary | Role of annexin A3 biomarker in with breast cancer patients | serum measurement of annexin A3 in breast cancer patients | 1 year |
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