Breast Cancer Clinical Trial
Official title:
Using PERS(PErsonalized Regimen Selection) Genetic Model Assistant Decision-making System of Neoadjuvant Chemotherapy for Breast Cancer Multicentric, Prospective, Randomized Controlled Phase III Clinical Study
This study aims to explore new PERS prediction model can improve the pathological complete response rate of neoadjuvant chemotherapy of breast cancer and disease-free survival.
This is a multi-center, prospective, randomized phase III clinical trial. Planning 320
cases.
This study will be divided into two stages. Phase one, 120 cases of local advanced breast
cancer (LABC)who need neoadjuvant chemotherapy. Gene prediction model test(PERS) is
performed before treatment(ddEC-T+/-H), verify the prediction efficacy of PERS.
Phase two, 200 cases of LABC primary resistant of antharcycline and taxans. Patients were
randomized to Arm ddEC-T+/-H and Arm PERS (regimens according to PERS,eg
NVB+DDP,capacitabine,gemcitabine and so on) pCR rate and DFS is observed.
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