Metformin in Breast Cancer, Visualized With Positron Emission Tomography

Status Completed

Clinical Trial Summary

The general purpose of the trial is to investigate whether metformin is taken up into the breast tumor. Studies in the last few years have shown an effect of metformin on cell proliferation on breast cancer. It is though unclear whether the effect on tumor is direct, indirect or a combination of the two. The investigators plan to:

- investigate if metformin is taken up in breast cancer using our novel 11C-metformin tracer and positron emission tomography (PET)

- investigate whether the uptake is correlated to the amounts of organic cation transporters (OCT1-3, MATE 1 &2 and PMAT) using quantitive polymerase chain reaction (qPCR).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02882581
Study type	Interventional
Source	Aarhus University Hospital
Contact
Status	Completed
Phase	Phase 1
Start date	August 2016
Completion date	October 2017

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