Breast Cancer Clinical Trial
Official title:
A Pilot Preoperative Trial of Ganetespib With Paclitaxel for Triple-Negative Breast Cancer
Based on preclinical data implicating GR, AR, and JAK/STAT activation as potent mechanisms of breast cancer cell survival despite chemotherapy administration (i.e. chemotherapy resistance), the study will test a novel approach for improving chemotherapy effectiveness by adding Hsp90 inhibition to antagonize the anti-apoptotic signaling pathways that are initiated via GR, AR, and JAK/STAT activation.
STUDY OBJECTIVES
Primary:
• To determine tumor GR, AR, JAK and other Hsp90 client protein expression before and after
two weeks of ganetespib monotherapy
Secondary:
- To determine the pathological Complete Response (pCR) rate associated with weekly
treatment of ganetespib plus paclitaxel followed by the combination treatment of
doxorubicin plus cyclophosphamide
- To characterize the toxicity of study treatment
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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