Breast Cancer Clinical Trial
Official title:
A Phase Ib/II Study of Pembrolizumab Plus Chemotherapy in Patients With Advanced Cancer (PembroPlus)
The Phase Ib and II cohorts will enroll patients with metistatic solid tumors.
Phase II only will enroll the following patients:
Patients with metastatic sarcoma to be enrolled in the following 4 arms: pembro plus
gemcitabine, pembro plus gemcitabine and docetaxel, pembro plus gemcitabine and vinorelbine,
and pembro plus liposomal doxorubicin.
Patients with metastatic pancreatic adenocarcinoma to be enrolled in the pembro plus
gemcitabine and nab-paclitaxel arm.
Patients with extensive-stage small cell lung cancer to be enrolled in the pembro plus
irinotecan arm.
Patients with ER+ breast cancer to be enrolled in the pembro and vinorelbine arm.
Patients with ovarian cancer to be enrolled in the pembroplus liposomal doxorubicin arm.
Patients with metastatic TNBC (ER/PR/HER2 negative) to be enrolled in the pembro plus
gemcitabine arm.
Pembrolizumab 2mg/kg administered intravenously over 30 minutes every 3 weeks. ;
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