Breast Cancer Clinical Trial
Official title:
Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer
NCT number | NCT02290834 |
Other study ID # | 14-217 |
Secondary ID | |
Status | Recruiting |
Phase | N/A |
First received | |
Last updated | |
Start date | March 2015 |
Est. completion date | January 2027 |
This research study evaluates the effect of chemotherapy on cognition (thinking) and the brain in people with breast cancer.
Status | Recruiting |
Enrollment | 200 |
Est. completion date | January 2027 |
Est. primary completion date | January 2026 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 60 Years and older |
Eligibility | Inclusion Criteria: - Breast cancer patients treated with chemotherapy- Group 1 (experimental group) - Participants must meet the following criteria on screening examination to be eligible to participate in the behavioral +/- imaging components of study - New diagnosis histologically confirmed invasive breast cancer - Treatment plan to include chemotherapy - Female subjects age = 60 years. - Life expectancy = 1 year - Karnofsky Performance Score (KPS) = 80 - Ability to understand and the willingness to sign a written informed consent document. - Non-treated breast cancer patient controls- Group 2 (control group) - Participants must meet the following criteria on screening examination to be eligible to participate in the behavioral +/- imaging components of study: - New diagnosis histologically confirmed invasive breast cancer - Treatment plan does not include chemotherapy - Age = 60 years. - Life expectancy = 1 year - Karnofsky Performance Score (KPS) = 80 - Ability to understand and the willingness to sign a written informed consent document. - Healthy control subjects- Group 3 (control group) - Participants must meet the following criteria on screening examination to be eligible to participate in the behavioral +/- imaging components of study: - Age = 60 years. - Life expectancy = 1 year - Karnofsky Performance Score (KPS) = 80 - Ability to understand and the willingness to sign a written informed consent document. - Participants with well-controlled vascular risk factors, such as treated hypertension, treated hyperlipidemia or well-controlled Type II diabetes (glucose levels <250) may be included. - Serum Pregnancy Testing: STAT quantitative serum hCG pregnancy testing for all women of childbearing potential. Imaging will not start until and unless the test result returns negative. Exclusion Criteria: - Participants who exhibit any of the following conditions at screening will not be eligible for admission into the study: - Participants with clinical or radiographic evidence of metastatic CNS disease - Subjects with MMSE scores below 24 - Active or history of major psychiatric disorders such as schizophrenia, schizoaffective disorder, major affective disorder in mid-life, or treatment with ECT (Mild depression that is well treated with stable dose of SSRI antidepressants may be allowed). - Substance abuse within the past 2 years - Huntington's disease, hydrocephalus or seizure disorder - In addition to exclusion criteria above, participants who exhibit any of the following conditions at screening will not be eligible for admission into imaging portion of the study: - Participants with contraindications to MRI (i.e., implanted metal including pacemakers, cerebral spinal fluid shunts, aneurysm clips, artificial heart valves, ear implants or metal/foreign objects in the eyes and those with a history of claustrophobia), injuries to the eyes with metal without X-ray documentation that metal was removed |
Country | Name | City | State |
---|---|---|---|
United States | Massachusetts General Hospital | Boston | Massachusetts |
United States | Massachusetts General Hospital/North Shore Cancer Center | Salem | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Massachusetts General Hospital |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in cognitive performance scores | Baseline, immediately after completion of chemo, and 6 months after completion of chemotherapy | ||
Secondary | Correlation between baseline amyloid accumulation in the brain and change in cognitive performance | Baseline, 6 months after completion of chemotherapy | ||
Secondary | Correlation between baseline tau accumulation in the brain and change in cognitive performance | Baseline, 6 months after completion of chemotherapy | ||
Secondary | Correlation between change in tau accumulation in the brain (from baseline to 6 months after completion of chemotherapy) and change in cognitive performance (from baseline to 6 months after completion of chemotherapy) | Baseline, 6 months after completion of chemotherapy |
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