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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT02290834
Other study ID # 14-217
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date March 2015
Est. completion date January 2027

Study information

Verified date March 2024
Source Massachusetts General Hospital
Contact Edwin Nunez
Phone 617-643-4395
Email ENUNEZ2@partners.org
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This research study evaluates the effect of chemotherapy on cognition (thinking) and the brain in people with breast cancer.


Description:

- This study is being done to study effects of chemotherapy (cancer treatment) on the brain and cognition (thinking). "Chemo-brain" is a term sometimes used to refer to effects of chemotherapy on the brain and cognition (thinking). - This study is being done to test for "chemo-brain" in older adults with breast cancer treated with chemotherapy, and to identify people who are most likely to be affected. The investigators will look at thinking abilities and brain images before and after chemotherapy to see if it can help identify people at risk for cognitive side effects of the treatment, and to better understand effects of treatment on brain structure and function. - The investigators are looking for participants who have either been recently recently diagnosed breast cancer participant or a healthy volunteer. - What is involved in the study: - Memory and Thinking Tests - Imaging: Either MRI/or MRI and PET Scans


Recruitment information / eligibility

Status Recruiting
Enrollment 200
Est. completion date January 2027
Est. primary completion date January 2026
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 60 Years and older
Eligibility Inclusion Criteria: - Breast cancer patients treated with chemotherapy- Group 1 (experimental group) - Participants must meet the following criteria on screening examination to be eligible to participate in the behavioral +/- imaging components of study - New diagnosis histologically confirmed invasive breast cancer - Treatment plan to include chemotherapy - Female subjects age = 60 years. - Life expectancy = 1 year - Karnofsky Performance Score (KPS) = 80 - Ability to understand and the willingness to sign a written informed consent document. - Non-treated breast cancer patient controls- Group 2 (control group) - Participants must meet the following criteria on screening examination to be eligible to participate in the behavioral +/- imaging components of study: - New diagnosis histologically confirmed invasive breast cancer - Treatment plan does not include chemotherapy - Age = 60 years. - Life expectancy = 1 year - Karnofsky Performance Score (KPS) = 80 - Ability to understand and the willingness to sign a written informed consent document. - Healthy control subjects- Group 3 (control group) - Participants must meet the following criteria on screening examination to be eligible to participate in the behavioral +/- imaging components of study: - Age = 60 years. - Life expectancy = 1 year - Karnofsky Performance Score (KPS) = 80 - Ability to understand and the willingness to sign a written informed consent document. - Participants with well-controlled vascular risk factors, such as treated hypertension, treated hyperlipidemia or well-controlled Type II diabetes (glucose levels <250) may be included. - Serum Pregnancy Testing: STAT quantitative serum hCG pregnancy testing for all women of childbearing potential. Imaging will not start until and unless the test result returns negative. Exclusion Criteria: - Participants who exhibit any of the following conditions at screening will not be eligible for admission into the study: - Participants with clinical or radiographic evidence of metastatic CNS disease - Subjects with MMSE scores below 24 - Active or history of major psychiatric disorders such as schizophrenia, schizoaffective disorder, major affective disorder in mid-life, or treatment with ECT (Mild depression that is well treated with stable dose of SSRI antidepressants may be allowed). - Substance abuse within the past 2 years - Huntington's disease, hydrocephalus or seizure disorder - In addition to exclusion criteria above, participants who exhibit any of the following conditions at screening will not be eligible for admission into imaging portion of the study: - Participants with contraindications to MRI (i.e., implanted metal including pacemakers, cerebral spinal fluid shunts, aneurysm clips, artificial heart valves, ear implants or metal/foreign objects in the eyes and those with a history of claustrophobia), injuries to the eyes with metal without X-ray documentation that metal was removed

Study Design


Intervention

Other:
Cognitive, functional and subjective assessments
Cognitive and functional assessments
Device:
MRI
Magnetic Resonance Imaging (MRI) Scan
Radiation:
PET Scan
Positron Emission Tomography (PET) Scan

Locations

Country Name City State
United States Massachusetts General Hospital Boston Massachusetts
United States Massachusetts General Hospital/North Shore Cancer Center Salem Massachusetts

Sponsors (1)

Lead Sponsor Collaborator
Massachusetts General Hospital

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Change in cognitive performance scores Baseline, immediately after completion of chemo, and 6 months after completion of chemotherapy
Secondary Correlation between baseline amyloid accumulation in the brain and change in cognitive performance Baseline, 6 months after completion of chemotherapy
Secondary Correlation between baseline tau accumulation in the brain and change in cognitive performance Baseline, 6 months after completion of chemotherapy
Secondary Correlation between change in tau accumulation in the brain (from baseline to 6 months after completion of chemotherapy) and change in cognitive performance (from baseline to 6 months after completion of chemotherapy) Baseline, 6 months after completion of chemotherapy
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