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HER2-Peptide Vaccination of Patients With Solid Tumors — HER2  

Breast Cancer Clinical Trial

Official title:
A Phase 1 Study of Peptide Vaccination for the Treatment of Patients With Solid Tumors Moderately Expressing HER2/Neu

Clinical Trial Summary

Investigation of peptide vaccination targeting HER2/neu in patients with metastasized breast or gastric cancer with moderate HER2/neu expression.

Clinical Trial Description

This is an interventional phase I clinical study to investigate the safety, tolerability and efficacy of HER2-derived peptide vaccination. HLA-A2+ patients with stage IV metastasized breast or gastric cancer with HER2 expression (IHC Score 2+) without gene amplification proved by FISH analysis, with documented stable disease or objective response after at least first line systemic chemotherapy/radiotherapy for advanced disease who have not been treated for the underlying malignant disease for 4 weeks with chemo-, radio- or immunotherapy will be included into the study. The aim of the study is to show safety and tolerability of this immunotherapeutic approach and to investigate efficacy of the immunotherapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02276300
Study type Interventional
Source Technische Universität München
Contact
Status Completed
Phase Phase 1
Start date December 2014
Completion date July 13, 2018
View Details
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