Breast Cancer Clinical Trial
Official title:
Multicentric Phase III Trial of Superiority of Stereotactic Body Radiation Therapy in Patients With Metastatic Breast Cancer in First-line Treatment
The previous reported phase I study allows us to prospectively define the optimal total dose
in different metastatic locations (88). However, several questions are still unanswered such
as the adequate timing of the stereotactic body radiation therapy (SBRT) in oligometastatic
disease. Indeed, there are two different oligometastatic states: "de novo", i.e. occurring at
first metastatic presentation without any previous systemic therapy; and "secondary", defined
as residual disease after systemic treatment.
The investigators wish to prospectively study the role of metastases SBRT with curative
intent in de novo oligometastatic disease.
This clinical trial would be the first randomized study studying SBRT at onset of the
metastatic disease. If this trial shows a PFS improvement, it will definitively change the
standard of treatment and it will highlight SBRT as a key treatment of metastatic disease. It
will confirm the oligometastasis hypothesis as well as the Simon Norton hypothesis (92).
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