Breast Cancer Clinical Trial
Official title:
Hippocampal Predictors of Cognitive Impairment (HippoPCI) in Breast Cancer Patients
The purpose of this study is to improve our understanding of potential changes in size, shape and activity in some brain areas that can occur in women receiving different types of Breast Cancer therapy, and how these changes are related to the development of mild cognitive impairment as the result of these treatments.
This study aims to identify neuroimaging biomarkers for predicting mild cognitive impairment
(MCI) in breast cancer patients receiving adjuvant chemo and/or hormonal therapy by examining
hippocampal-cortical neurocircuitry. Adjuvant therapies increase long-term survival, but
produce changes in cognitive function in 30% (up to 70%) of women on average with breast
cancer. Cognitive decline negatively impacts quality of life in patients and their
supporters. Therefore, early identification of patients at risk for developing
treatment-related cognitive impairment is needed to develop potential prevention or treatment
options and prevent further decline. Our recent work demonstrates that patients receiving
adjuvant hormonal treatment exhibit decline in cognition as soon as three months post
treatment. Although neuroimaging studies have identified brain changes associated with
chemotherapy ("chemo brain", no investigation has assessed the type and severity of such
changes following hormonal therapy, nor has any study determined which individuals are at
greatest risk for cognitive impairment.
Our central hypothesis is that measures of the hippocampal-cortical integrity can be used to
predict cognitive decline, and changes of specific domains of cognitive performance in
patients receiving adjuvant therapy over time will be related to changes in specific
components of this circuitry over time.
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